ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
GABAC receptor sensitivity is modulated by interaction with MAP1B.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 48 citations in OpenAlex.
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- The effect of electric stimulation of various frequencies and durations on microtubules in frog motor axon terminals.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections · 2014Article
- A presynaptic role of microtubule-associated protein 1/Futsch in Drosophila: regulation of active zone number and neurotransmitter release.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- mRNA and protein expression for novel GABAA receptors θ and ρ2 are altered in schizophrenia and mood disorders; relevance to FMRP-mGluR5 signaling pathway.Translational psychiatry · 2013Article
- An Update on GABAρ Receptors.Current neuropharmacology · 2010Article
- Transcriptome profile in Williams-Beuren syndrome lymphoblast cells reveals gene pathways implicated in glucose intolerance and visuospatial construction deficits.Human genetics · 2010Article
- Amyloid-beta peptide binds to microtubule-associated protein 1B (MAP1B).Neurochemistry international · 2008Article
- Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.The Journal of physiology · 2008Article
- Kinetic properties of GABA rho1 homomeric receptors expressed in HEK293 cells.Biophysical journal · 2006Article
- Localization of microtubule-associated protein (MAP) 1B in the postsynaptic densities of the rat cerebral cortex.Cellular and molecular neurobiology · 2003Article
- Amino acid transporters: roles in amino acid sensing and signalling in animal cells.The Biochemical journal · 2003Review
- Control of intracellular chloride concentration and GABA response polarity in rat retinal ON bipolar cells.The Journal of physiology · 2002Article
- Receptor for activated C kinase-1 facilitates protein kinase C-dependent phosphorylation and functional modulation of GABA(A) receptors with the activation of G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
GABA(C) receptors contain rho subunits and mediate feedback inhibition from retinal amacrine cells to bipolar cells. We previously identified the cytoskeletal protein MAP1B as a rho1 subunit anchoring protein. Here, we analyze the structural basis and functional significance of the MAP1B-rho1 interaction. Twelve amino acids at the C terminus of the large intracellular loop of rho1 (and also rho2) are sufficient for interaction with MAP1B. Disruption of the MAP1B-rho interaction in bipolar cells in retinal slices decreased the EC(50) of their GABA(C) receptors, doubling the receptors' current at low GABA concentrations without affecting their maximum current at high concentrations. Thus, anchoring to the cytoskeleton lowers the sensitivity of GABA(C) receptors and provides a likely site for functional modulation of GABA(C) receptor-mediated inhibition.
Indexed as
Identifiers
11102469PMC6773065W2797489511What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.