ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Independence of and interactions between GABA-, glutamate-, and acetylcholine-activated Cl conductances in Aplysia neurons.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 25 citations in OpenAlex.
- Evolution of glutamatergic signaling and synapses.Neuropharmacology · 2021Review
- Characterization of Brain Dysfunction Induced by Bacterial Lipopeptides That Alter Neuronal Activity and Network in Rodent Brains.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Article
- The actions of chloride channel blockers, barbiturates and a benzodiazepine on Caenorhabditis elegans glutamate- and ivermectin-gated chloride channel subunits expressed in Xenopus oocytes.Invertebrate neuroscience : IN · 2009Article
- Glutamatergic and GABAergic effects of fipronil on olfactory learning and memory in the honeybee.Invertebrate neuroscience : IN · 2009Article
- Aplysia cys-loop glutamate-gated chloride channels reveal convergent evolution of ligand specificity.Journal of molecular evolution · 2009Article
- Acetylcholine receptors in spider peripheral mechanosensilla.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2006Article
- Cyclic nucleotides induce long-term augmentation of glutamate-activated chloride current in molluscan neurons.Cellular and molecular neurobiology · 2005Article
- Concerted GABAergic actions of Aplysia feeding interneurons in motor program specification.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- The shift of the reversal potential of glutamate-activated chloride current in molluscan neurons caused by 8-Br-cAMP.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
- Long-term potentiation of the glutamate-activated inward current induced by 8-Br-cGMP in nerve cell.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In certain Aplysia neurons, glutamate, GABA, and acetylcholine (ACh) all elicit desensitizing Cl-dependent responses. This fact and the finding that the glutamate and GABA responses "cross-desensitize" led to the suggestion (Swann and Carpenter, 1975; King and Carpenter, 1987) that the responses to these transmitters were mediated by the same receptor-channel complex. This hypothesis is incompatible with the demonstration given here that the GABA- and glutamate-gated channels are clearly distinct; the GABA channel, but not the glutamate channel, shows outward rectification (Matsumoto, 1982; King and Carpenter, 1987, 1989) and is selectively blocked by intracellular sulfate. Exploiting these distinctive characteristics and the independent expression of the receptors in some cells, we have been able to reevaluate the so-called cross-desensitization by analyzing the ability of GABA, glutamate, and other agonists to interact with each of the receptor molecules. The cross-desensitization was found to be exclusively attributable to the ability of GABA to interact with the glutamate receptor (Oyama et al., 1990). The GABA receptor is unaffected by glutamate. Nevertheless, in cells expressing both receptors, glutamate can reduce the GABA response by auto-desensitizing the part of the response that is mediated by the glutamate receptor. No interactions were observed between ACh-induced responses and either of the responses elicited by the amino acids. The invertebrate glutamate-gated Cl channels that have been cloned resemble the vertebrate glycine receptor (Vassilatis et al., 1997). Our pharmacological evaluation of the molluscan glutamate receptor points in the same direction.
Indexed as
Identifiers
11102462PMC6773048W2114235659What OpenQuestion holds
Registered trials
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