ArticleGenetics2000
Testing for concordant equilibria between population samples.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 15 citations in OpenAlex.
- IL8 gene as modifier of cystic fibrosis: unraveling the factors which influence clinical variability.Human genetics · 2016Article
- Loss of IL-15 receptor α alters the endurance, fatigability, and metabolic characteristics of mouse fast skeletal muscles.The Journal of clinical investigation · 2011Article
- Stepwise haplotype analysis: are LD patterns repeatable?Human genomics · 2006Article
- Contrasting linkage-disequilibrium patterns between cases and controls as a novel association-mapping method.American journal of human genetics · 2006Article
- Integrated analysis of genetic data with R.Human genomics · 2006Review
- ACTN3 genotype is associated with human elite athletic performance.American journal of human genetics · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A substantial body of theory has been developed to assess the effect of evolutionary forces on the distribution of genotypes, both single and multilocus, within populations. One area where the potential for application of this theory has not been fully appreciated concerns the extent to which population samples differ. Within populations, the divergence of genotype or haplotype frequencies from that expected under Hardy-Weinberg (HW) or linkage equilibrium can be measured as disequilibria coefficients. To assess population samples for concordant equilibria, an analytical framework for comparing disequilibria coefficients between populations is necessary. Here we present log-linear models to evaluate such hypotheses. These models have broad utility ranging from conventional population genetics to genetic epidemiology. We demonstrate the use of these log-linear models (1) as a test for genetic association with disease and (2) as a test for different levels of linkage disequilibria between human populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.