ArticleGenetics2000
Sequence variation at two eosinophil-associated ribonuclease loci in humans.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Evaluation of Eosinophilic Cationic Protein as a Marker of Alveolar and Cystic Echinococcosis.Pathogens (Basel, Switzerland) · 2022Article
- Human RNase3 immune modulation by catalytic-dependent and independent modes in a macrophage-cell line infection model.Cellular and molecular life sciences : CMLS · 2021Article
- Genetic variants of RNASE3 (ECP) and susceptibility to severe malaria in Senegalese population.Malaria journal · 2018Article
- Eosinophil-Derived Neurotoxin (EDN/RNase 2) and the Mouse Eosinophil-Associated RNases (mEars): Expanding Roles in Promoting Host Defense.International journal of molecular sciences · 2015Review
- Effect of eosinophil cationic protein on human oral squamous carcinoma cell viability.Molecular and clinical oncology · 2015Article
- Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed.World journal of gastroenterology · 2012Article
- Genetic diversity of human RNase 8.BMC genomics · 2012Article
- Analysing the eosinophil cationic protein--a clue to the function of the eosinophil granulocyte.Respiratory research · 2011Review
- Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.PloS one · 2011Article
- Associations of ECP (eosinophil cationic protein)-gene polymorphisms to allergy, asthma, smoke habits and lung function in two Estonian and Swedish sub cohorts of the ECRHS II study.BMC pulmonary medicine · 2010Article
- RNase A ribonucleases and host defense: an evolving story.Journal of leukocyte biology · 2008Review
- Transcriptional regulation of human eosinophil RNases by an evolutionary- conserved sequence motif in primate genome.BMC molecular biology · 2007Article
- The RNase a superfamily: generation of diversity and innate host defense.Molecular diversity · 2006Review
- Article
- Surface-exposed amino acids of eosinophil cationic protein play a critical role in the inhibition of mammalian cell proliferation.Molecular and cellular biochemistry · 2005Article
- Localized eosinophil degranulation mediates disease in tropical pulmonary eosinophilia.Infection and immunity · 2003Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Complementary advantageous substitutions in the evolution of an antiviral RNase of higher primates.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Contrasting evolution of the human leukocyte N-formylpeptide receptor subtypes FPR and FPRL1R.Genes and immunity · 2001Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Host defense against invading pathogens is of great importance to the survival of higher organisms. We have been studying the evolution of mammalian eosinophil-associated ribonucleases (EARs), which are members of the ribonuclease A superfamily with known antipathogen activities. Earlier studies showed that positive selection promoted rapid diversification of paralogous EAR genes in both primates and rodents. Intraspecifically, however, it is unknown whether these genes also have divergent alleles. The recent discovery that the gene repertoire of the EAR family is much larger in rodents than in primates has led us to consider the possibility that primates maintain a large number of polymorphic alleles to compensate for a smaller gene repertoire. Here we present sequences of 2417 nucleotides at the two EAR loci, the eosinophil-derived neurotoxin (EDN, RNase 2) and eosinophil cationic protein (ECP, RNase 3), from >50 human individuals. Our data demonstrate that the nucleotide diversities (0.06-0.11%) at these loci are typical for human nuclear genes, thus permitting us to reject this polymorphism hypothesis. No significant departure from neutrality is noted and no signs of overdominant selection are observed. Similar patterns were observed in a preliminary study of chimpanzees. In summary, our results suggest that the antipathogen functions of the primate EARs are conserved after they are established and that these proteins are not currently undergoing rapid diversification in response to challenge from invading microorganisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.