ArticleGenetics2000
Extensive amino acid polymorphism at the pgm locus is consistent with adaptive protein evolution in Drosophila melanogaster.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 49 citations in OpenAlex.
- Balanced Polymorphism at theGenes · 2022Article
- Molecular population genetics and selection in the glycolytic pathway.The Journal of experimental biology · 2011Review
- Flux control and excess capacity in the enzymes of glycolysis and their relationship to flight metabolism in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Article
- Multiple signatures of positive selection downstream of notch on the X chromosome in Drosophila melanogaster.Genetics · 2005Article
- Article
- Multiple mutations and gene duplications conferring organophosphorus insecticide resistance have been selected at the Rop-1 locus of the sheep blowfly, Lucilia cuprina.Journal of molecular evolution · 2005Article
- The role of natural selection in genetic differentiation of worldwide populations of Drosophila ananassae.Genetics · 2004Article
- Thermal selection of PGM allozymes in newly founded populations of the thermotolerant vent polychaete Alvinella pompejana.Proceedings. Biological sciences · 2004Article
- Article
- Latitudinal clines in Drosophila melanogaster: body size, allozyme frequencies, inversion frequencies, and the insulin-signalling pathway.Journal of genetics · 2003Article
- Influence of two Wolbachia strains on population structure of East African Drosophila simulans.Genetics · 2003Article
- Applications of selective neutrality tests to molecular ecology.Molecular ecology · 2002Review
- Distinguishing between selection and population expansion in an experimental lineage of bacteriophage T7.Genetics · 2002Article
- Doxycycline-induced expression of sense and inverted-repeat constructs modulates phosphogluconate mutase (Pgm) gene expression in adult Drosophila melanogaster.Genome biology · 2002Article
- The functional impact of Pgm amino acid polymorphism on glycogen content in Drosophila melanogaster.Genetics · 2001Article
- Clinal variation for amino acid polymorphisms at the Pgm locus in Drosophila melanogaster.Genetics · 2001Article
- Geographic selection in the small heat shock gene complex differentiating populations of Drosophila pseudoobscura.The Journal of heredityArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
PGM plays a central role in the glycolytic pathway at the branch point leading to glycogen metabolism and is highly polymorphic in allozyme studies of many species. We have characterized the nucleotide diversity across the Pgm gene in Drosophila melanogaster and D. simulans to investigate the role that protein polymorphism plays at this crucial metabolic branch point shared with several other enzymes. Although D. melanogaster and D. simulans share common allozyme mobility alleles, we find these allozymes are the result of many different amino acid changes at the nucleotide level. In addition, specific allozyme classes within species contain several amino acid changes, which may explain the absence of latitudinal clines for PGM allozyme alleles, the lack of association of PGM allozymes with the cosmopolitan In(3L)P inversion, and the failure to detect differences between PGM allozymes in functional studies. We find a significant excess of amino acid polymorphisms within D. melanogaster when compared to the complete absence of fixed replacements with D. simulans. There is also strong linkage disequilibrium across the 2354 bp of the Pgm locus, which may be explained by a specific amino acid haplotype that is high in frequency yet contains an excess of singleton polymorphisms. Like G6pd, Pgm shows strong evidence for a branch point enzyme that exhibits adaptive protein evolution.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.