ArticleGenetics2000
The Aspergillus nidulans xprF gene encodes a hexokinase-like protein involved in the regulation of extracellular proteases.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 42 citations in OpenAlex.
- Genomic Analysis of Hexokinase Genes in Foxtail Millet (International journal of molecular sciences · 2025Article
- Insights into the efficient degradation mechanism of extracellular proteases mediated byFrontiers in microbiology · 2024Article
- Structure and Expression Analysis ofInternational journal of molecular sciences · 2023Article
- Characterization of hexokinase gene family members inFrontiers in genetics · 2023Article
- Genome-Wide Identification and Characterization of Hexokinase Genes in Moso Bamboo (Frontiers in plant science · 2020Article
- Blocking hexose entry into glycolysis activates alternative metabolic conversion of these sugars and upregulates pentose metabolism in Aspergillus nidulans.BMC genomics · 2018Article
- Extreme Diversity in the Regulation of Ndt80-Like Transcription Factors in Fungi.G3 (Bethesda, Md.) · 2015Article
- A p53-like transcription factor similar to Ndt80 controls the response to nutrient stress in the filamentous fungus, Aspergillus nidulans.F1000Research · 2013Article
- Meiotic regulators Ndt80 and ime2 have different roles in Saccharomyces and Neurospora.Genetics · 2010Article
- Aspergillus fumigatus catalytic glucokinase and hexokinase: expression analysis and importance for germination, growth, and conidiation.Eukaryotic cell · 2010Article
- A regulator of Aspergillus fumigatus extracellular proteolytic activity is dispensable for virulence.Infection and immunity · 2009Article
- Mutations in genes encoding sorting nexins alter production of intracellular and extracellular proteases in Aspergillus nidulans.Genetics · 2009Article
- PepJ is a new extracellular proteinase of Aspergillus nidulans.Folia microbiologica · 2009Article
- Article
- The interaction of induction, repression and starvation in the regulation of extracellular proteases in Aspergillus nidulans: evidence for a role for CreA in the response to carbon starvation.Current genetics · 2008Article
- Characterization of regulatory non-catalytic hexokinases in Aspergillus nidulans.Molecular genetics and genomics : MGG · 2007Article
- Lessons from the genome sequence of Neurospora crassa: tracing the path from genomic blueprint to multicellular organism.Microbiology and molecular biology reviews : MMBR · 2004Review
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The extracellular proteases of Aspergillus nidulans are produced in response to limitation of carbon, nitrogen, or sulfur, even in the absence of exogenous protein. Mutations in the A. nidulans xprF and xprG genes have been shown to result in elevated levels of extracellular protease in response to carbon limitation. The xprF gene was isolated and sequence analysis indicates that it encodes a 615-amino-acid protein, which represents a new type of fungal hexokinase or hexokinase-like protein. In addition to their catalytic role, hexokinases are thought to be involved in triggering carbon catabolite repression. Sequence analysis of the xprF1 and xprF2 alleles showed that both alleles contain nonsense mutations. No loss of glucose or fructose phosphorylating activity was detected in xprF1 or xprF2 mutants. There are two possible explanations for this observation: (1) the xprF gene may encode a minor hexokinase or (2) the xprF gene may encode a protein with no hexose phosphorylating activity. Genetic evidence suggests that the xprF and xprG genes are involved in the same regulatory pathway. Support for this hypothesis was provided by the identification of a new class of xprG(-) mutation that suppresses the xprF1 mutation and results in a protease-deficient phenotype.
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