ArticleGenetics2000
Experimental analysis of molecular events during mutational periodic selections in bacterial evolution.
Article in Genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 70 citations in OpenAlex.
- Global pleiotropic effects in adaptively evolvedOpen biology · 2022Article
- Evolutionary dynamics and structural consequences of de novo beneficial mutations and mutant lineages arising in a constant environment.BMC biology · 2021Article
- Evolutionary Rescue of an EnvironmentalFrontiers in microbiology · 2020Article
- Evolutionary Changes after Translational Challenges Imposed by Horizontal Gene Transfer.Genome biology and evolution · 2019Article
- High-Throughput Identification of Adaptive Mutations in Experimentally Evolved Yeast Populations.PLoS genetics · 2016Article
- Article
- Simple phenotypic sweeps hide complex genetic changes in populations.Genome biology and evolution · 2015Article
- The dynamics of diverse segmental amplifications in populations of Saccharomyces cerevisiae adapting to strong selection.G3 (Bethesda, Md.) · 2014Article
- Starvation induces phenotypic diversification and convergent evolution in Vibrio vulnificus.PloS one · 2014Article
- A case of adaptation through a mutation in a tandem duplication during experimental evolution in Escherichia coli.BMC genomics · 2013Article
- The role of environmental factors on the evolution of phenotypic diversity in vesicular stomatitis virus populations.The Journal of general virology · 2013Article
- Normal mutation rate variants arise in a Mutator (Mut S) Escherichia coli population.PloS one · 2013Article
- Insertion sequence-driven evolution of Escherichia coli in chemostats.Journal of molecular evolution · 2011Article
- Beneficial mutations and the dynamics of adaptation in asexual populations.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Identification and dynamics of a beneficial mutation in a long-term evolution experiment with Escherichia coli.BMC evolutionary biology · 2009Article
- Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae.Nature genetics · 2008Article
- Hitchhiking both ways: effect of two interfering selective sweeps on linked neutral variation.Genetics · 2008Article
- Perceiving molecular evolution processes in Escherichia coli by comprehensive metabolite and gene expression profiling.Genome biology · 2008Article
- Tests of parallel molecular evolution in a long-term experiment with Escherichia coli.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Genotype-by-environment interactions influencing the emergence of rpoS mutations in Escherichia coli populations.Genetics · 2006Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A fundamental feature of bacterial evolution is a succession of adaptive mutational sweeps when fitter mutants take over a population. To understand the processes involved in mutational successions, Escherichia coli continuous cultures were analyzed for changes at two loci where mutations provide strong transport advantages to fitness under steady-state glucose limitation. Three separate sweeps, observed as classic periodic selection events causing a change in the frequency of neutral mutations (in fhuA causing phage T5 resistance), were identified with changes at particular loci. Two of the sweeps were associated with a reduction in the frequency of neutral mutations and the concurrent appearance of at least 13 alleles at the mgl or mlc loci, respectively. These mgl and mlc polymorphisms were of many mutational types, so were not the result of a mutator or directed mutation event. The third sweep observed was altogether distinct and involved hitchhiking between T5 resistance and advantageous mgl mutations. Moreover, the hitchhiking event coincided with an increase in mutation rates, due to the transient appearance of a strong mutator in the population. The spectrum of mgl mutations among mutator isolates was distinct and due to mutS. The mutator-associated periodic selection also resulted in mgl and fhuA polymorphism in the sweeping population. These examples of periodic selections maintained significant genotypic diversity even in a rapidly evolving culture, with no individual "winner clone" or genotype purging the population.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.