ArticleJournal of clinical microbiology2000
Comparative genotyping of Candida albicans bloodstream and nonbloodstream isolates at a polymorphic microsatellite locus.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 55 citations in OpenAlex.
- Genetic diversity and antifungal susceptibility of Candida albicans isolated from Iranian patients.Medical mycology · 2019Article
- Investigating Clinical Issues by Genotyping of Medically Important Fungi: Why and How?Clinical microbiology reviews · 2017Review
- Antifungal effects of the aqueous and ethanolic leaf extracts ofCurrent medical mycology · 2016Article
- Article
- Genetic variability of Candida albicans Sap8 propeptide in isolates from different types of infection.BioMed research international · 2015Article
- Highly discriminatory variable-number tandem-repeat markers for genotyping of Trichophyton interdigitale strains.Journal of clinical microbiology · 2014Article
- Endemic genotypes of Candida albicans causing fungemia are frequent in the hospital.Journal of clinical microbiology · 2013Article
- Genotyping reveals no link between Candida albicans genotype and vaginitis severity in Turkish women.Mycopathologia · 2013Article
- Molecular fingerprints to identify Candida species.BioMed research international · 2013Review
- Diagnostic issues, clinical characteristics, and outcomes for patients with fungemia.Journal of clinical microbiology · 2011Article
- Typing Candida albicans oral isolates from healthy brazilian schoolchildren using multilocus enzyme electrophoresis reveals two highly polymorphic taxa.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2011Article
- National surveillance of fungemia in Denmark (2004 to 2009).Journal of clinical microbiology · 2011Article
- Multicenter collaborative study for standardization of Candida albicans genotyping using a polymorphic microsatellite marker.Journal of clinical microbiology · 2010Article
- Molecular analysis of Candida albicans isolates from clinical specimens.Mycopathologia · 2010Article
- A new type of DNA polymorphism identified in the species-specific DNA region originating from the Candida albicans mitochondrial genome.Current microbiology · 2009Article
- Comparison of microsatellite length polymorphism and multilocus sequence typing for DNA-Based typing of Candida albicans.Journal of clinical microbiology · 2007Article
- A cautionary tale: Lack of consistency in allele sizes between two laboratories for a published multilocus microsatellite typing system.Journal of clinical microbiology · 2007Article
- New microsatellite multiplex PCR for Candida albicans strain typing reveals microevolutionary changes.Journal of clinical microbiology · 2005Article
- Use of microsatellite markers and gene dosage to quantify gene copy numbers in Candida albicans.Journal of clinical microbiology · 2005Article
- Analysis of polymorphic microsatellite markers for typing Penicillium marneffei isolates.Journal of clinical microbiology · 2004Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molecular typing studies have shown that the predominant form of reproduction of Candida albicans is clonal and that, in a majority of situations, persistent or recurrent infections are due to a unique strain. Characterization of distinct subpopulations and correlation with clinical features may thus be important to understanding the pathogenesis of candidiasis. In a clonal model, a unique polymorphic marker may identify populations with different biological properties. We therefore compared 48 bloodstream isolates and 48 nonbloodstream matched strains of C. albicans at the elongation factor 3-encoding gene (CEF3) polymorphic microsatellite locus of C. albicans. Sizing of the alleles was performed by automated capillary electrophoresis. A new, 137-bp allele was characterized, and seven nondescribed combinations were observed, resulting in 15 and 11 distinct CEF3 profiles in bloodstream and control strains, respectively. Genotypes 126-135, 130-136, and 131-131 accounted for 60.4% of both bloodstream and control strains. Four bloodstream isolates but no control strains displayed the 135-135 combination. None of the other genotypes was present at an increased frequency in bloodstream isolates. Bloodstream and nonbloodstream strains of C. albicans thus have a heterogeneous structure at the CEF3 locus, with three major and multiple minor allelic combinations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.