ArticleJournal of clinical microbiology2000
Transfusion-acquired, autochthonous human babesiosis in Japan: isolation of Babesia microti-like parasites with hu-RBC-SCID mice.
Article in Journal of clinical microbiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 98 citations in OpenAlex.
- Article
- Diversity of piroplasma species in small rodents and ticks captured in suburbs of Gifu City, central Japan.The Journal of veterinary medical science · 2025Article
- Development of Multiplex Assays for the Identification of ZoonoticPathogens (Basel, Switzerland) · 2024Article
- Molecular detection ofInternational journal for parasitology. Parasites and wildlife · 2024Article
- Human Babesia odocoilei and Bartonella spp. co-infections in the Americas.Parasites & vectors · 2024Article
- Evolutionary analysis of Babesia vulpes and Babesia microti-like parasites.Parasites & vectors · 2022Article
- Comparative single-cell transcriptional atlases of Babesia species reveal conserved and species-specific expression profiles.PLoS biology · 2022Article
- A Review of Zoonotic Babesiosis as an Emerging Public Health Threat in Asia.Pathogens (Basel, Switzerland) · 2021Review
- The Global Emergence of Human Babesiosis.Pathogens (Basel, Switzerland) · 2021Review
- Generation of Novel Human Red Blood Cell-Bearing Humanized Mouse Models Based on C3-Deficient NOG Mice.Frontiers in immunology · 2021Article
- Emerging Tick-Borne Diseases.Clinical microbiology reviews · 2020Review
- Detection and characterization of an emerging type ofEmerging microbes & infections · 2019Article
- Case report of the patient source of the Babesia microti R1 reference strain and implications for travelers.Journal of travel medicine · 2018Article
- Article
- Detection of Kobe-type and Otsu-type Babesia microti in wild rodents in China's Yunnan province.Epidemiology and infection · 2017Article
- Ixodes persulcatus Ticks as Vectors for the Babesia microti U.S. Lineage in Japan.Applied and environmental microbiology · 2016Article
- Molecular detection and seroprevalence of Babesia microti among stock farmers in Khutul City, Selenge Province, Mongolia.The Korean journal of parasitology · 2014Article
- Identification of parasitic communities within European ticks using next-generation sequencing.PLoS neglected tropical diseases · 2014Article
- Human babesiosis in Europe: what clinicians need to know.Infection · 2013Review
- Natural history of Zoonotic Babesia: Role of wildlife reservoirs.International journal for parasitology. Parasites and wildlife · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have isolated piroplasms from a patient who developed the first case of human babesiosis in Japan by using NOD/shi-scid mice whose circulating erythrocytes (RBCs) had been replaced with human RBCs (hu-RBC-SCID mice). Following inoculation of the patient's blood specimen into hu-RBC-SCID mice, parasites proliferated within the human RBCs in the mice, resulting in a high level of parasitemia. Parasite DNA was prepared from blood samples of the patient and the mice, and the nuclear small-subunit rRNA gene (rDNA) was amplified and sequenced. Both DNA samples gave rise to identical sequences which showed the highest degree of homology (99.2%) with the Babesia microti rDNA. Because the patient had received a blood transfusion before the onset of babesiosis, we investigated the eight donors who were involved. Their archived blood samples were analyzed for specific antibody and parasite DNA; only a single donor was found to be positive by both tests, and the parasite rDNA sequence from the donor coincided with that derived from the patient. The donor's serum exhibited a high antibody titer against the isolate from the patient, whereas it exhibited only a weak cross-reaction against B. microti strains isolated in the United States. We conclude that the first Japanese babesiosis case occurred due to a blood transfusion and that the etiological agent is an indigenous Japanese parasite which may be a geographical variant of B. microti. Our results also demonstrated the usefulness of hu-RBC-SCID mice for isolation of parasites from humans and for maintenance of the parasite infectivity for human RBCs.
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