Evidence map›Paper›PMID 11101217›Full record

ArticleJournal of biomolecular NMR2000

Sequence-specific NMR assignment of proteins by global fragment mapping with the program MAPPER.

P Güntert, M Salzmann, D Braun, K Wüthrich

Abstract read
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Article in Journal of biomolecular NMR, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 93 citations in OpenAlex.

  1. NMR Assignment through Linear Programming.Journal of global optimization : an international journal dealing with theoretical and computational aspects of seeking global optima and their applications in science, management and engineering · 2022
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  8. NMR resonance assignments of thrombin reveal the conformational and dynamic effects of ligation.Proceedings of the National Academy of Sciences of the United States of America · 2010
    Article
  9. Engineering a two-helix bundle protein for folding studies.Protein engineering, design & selection : PEDS · 2010
    Article
  10. Automated structure determination from NMR spectra.European biophysics journal : EBJ · 2009
    Review
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  12. Article
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  15. Contact replacement for NMR resonance assignment.Bioinformatics (Oxford, England) · 2008
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

P GüntertInstitut für Molekularbiologie und Biophysik, ETH-Hönggerberg, Zürich, Switzerland. guenter@mol.biol.ethz.ch
M Salzmann
D Braun
K Wüthrich
ETH Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A new program, MAPPER, for semiautomatic sequence-specific NMR assignment in proteins is introduced. The program uses an input of short fragments of sequentially neighboring residues, which have been assembled based on sequential NMR connectivities and for which either the 13C(alpha) and 13C(beta) chemical shifts or data on the amino acid type from other sources are known. MAPPER then performs an exhaustive search for self-consistent simultaneous mappings of all these fragments onto the protein sequence. Compared to using only the individual mappings of the spectroscopically connected fragments, the global mapping adds a powerful new constraint, which results in resolving many otherwise intractable ambiguities. In an initial application, virtually complete sequence-specific assignments were obtained for a 110 kDa homooctameric protein, 7,8-dihydroneopterin aldolase from Staphylococcus aureus.

Indexed as

SoftwareAldehyde-LyasesAlgorithmsAmino Acid SequenceBinding SitesCarbon IsotopesMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProteinsStaphylococcus aureusAldehyde-LyasesCarbon Isotopesdihydroneopterin aldolasePeptide FragmentsProteins

Identifiers

PMID11101217
OpenAlexW1507046264

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.