ReviewGene expression2000
Chemical approaches to control gene expression.
Review in Gene expression, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Symmetry-guided fusion converts weak liver pyruvate kinase inhibitors into potent allosteric activators.RSC medicinal chemistry · 2026Article
- Alternative Approach to Sequence-Specific Recognition of DNA: Cooperative Stacking of Dication Dimers─Sensitivity to Compound Curvature, Aromatic Structure, and DNA Sequence.ACS chemical biology · 2025Article
- Deciphering the interaction of flavones with calf thymus DNA and octamer DNA sequence (CCAATTGG)RSC advances · 2021Article
- Organoplatinum(II) Complexes Self-Assemble and Recognize AT-Rich Duplex DNA Sequences.Inorganic chemistry · 2021Article
- Regulation of the Ras-Related Signaling Pathway by Small Molecules Containing an Indole Core Scaffold: A Potential Antitumor Therapy.Frontiers in pharmacology · 2020Review
- Synthetic immunity by remote control.Theranostics · 2020Review
- A novel gene regulator, pyrrole-imidazole polyamide targeting ABCA1 gene increases cholesterol efflux from macrophages and plasma HDL concentration.Journal of molecular medicine (Berlin, Germany) · 2014Article
- Programmable DNA-binding small molecules.Bioorganic & medicinal chemistry · 2013Review
- Inhibition of N-terminal lysines acetylation and transcription factor assembly by epirubicin induced deranged cell homeostasis.PloS one · 2012Article
- Specificity landscapes of DNA binding molecules elucidate biological function.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- CSI-FID: high throughput label-free detection of DNA binding molecules.Bioorganic & medicinal chemistry letters · 2009Article
- Small molecules affecting transcription in Friedreich ataxia.Pharmacology & therapeutics · 2007Review
- Alkylation of template strand of coding region causes effective gene silencing.Nucleic acids research · 2006Article
- DNA sequence recognition by an isopropyl substituted thiazole polyamide.Nucleic acids research · 2004Article
- Nuclear localization of pyrrole-imidazole polyamide-fluorescein conjugates in cell culture.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Daunorubicin-induced variations in gene transcription: commitment to proliferation arrest, senescence and apoptosis.The Biochemical journal · 2003Article
- Promoter-specific inhibition of transcription by daunorubicin in Saccharomyces cerevisiae.The Biochemical journal · 2002Article
- Thermodynamic characterization of the multivalent binding of chartreusin to DNA.Nucleic acids research · 2002Article
- Sequence-specific protection of plasmid DNA from restriction endonuclease hydrolysis by pyrrole-imidazole-cyclopropapyrroloindole conjugates.Nucleic acids research · 2002Article
- Promoter scanning for transcription inhibition with DNA-binding polyamides.Molecular and cellular biology · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A current goal in molecular medicine is the development of new strategies to interfere with gene expression in living cells in the hope that novel therapies for human disease will result from these efforts. This review focuses on small-molecule or chemical approaches to manipulate gene expression by modulating either transcription of messenger RNA-coding genes or protein translation. The molecules under study include natural products, designed ligands, and compounds identified through functional screens of combinatorial libraries. The cellular targets for these molecules include DNA, messenger RNA, and the protein components of the transcription, RNA processing, and translational machinery. Studies with model systems have shown promise in the inhibition of both cellular and viral gene transcription and mRNA utilization. Moreover, strategies for both repression and activation of gene transcription have been described. These studies offer promise for treatment of diseases of pathogenic (viral, bacterial, etc.) and cellular origin (cancer, genetic diseases, etc.).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.