ArticleCurrent infectious disease reports2000
New Advances in the Pathogenesis and Pathophysiology of Bacterial Meningitis.
Article in Current infectious disease reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed, 26 citations in OpenAlex.
- Meta-analysis of studies comparing adjuvant dexamethasone to glycerol to improve clinical outcome of bacterial meningitis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2016Review
- Early neurologic complications and long-term sequelae of childhood bacterial meningitis in a limited-resource country (Kosovo).Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2013Review
- Circulating concentrations, cerebral output of the CINC-1 and blood–brain barrier disruption in Wistar rats after pneumococcal meningitis induction.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Dexamethasone treatment reverses cognitive impairment but increases brain oxidative stress in rats submitted to pneumococcal meningitis.Oxidative medicine and cellular longevity · 2011Article
- Chemotactic factors in cerebrospinal fluid during bacterial meningitis.Infection and immunity · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute bacterial meningitis continues to be a significant health concern, with a fatality rate of more than 30% in some studies. Although the face of bacterial meningitis has changed substantially over the past 15 years, this disease still causes significant mortality (particularly in underdeveloped countries) and neurological sequelae. Our understanding of the pathophysiology of bacterial meningitis continues to develop. Our understanding of the mechanisms of neuronal injury now includes the concept that many of the pathological changes are only secondary to the infection and that the human immune system contributes to the majority of the neuronal death. A complicated series of interactions among immune, vascular and central nervous system cells, cytokines and chemokines, matrix metalloproteinases and free radical molecules are ultimately responsible for many bacterial meningitis changes. We hope that a complete understanding of these processes will ultimately lead to better diagnostic techniques and improved treatments.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.