ArticleProceedings of the National Academy of Sciences of the United States of America2000
SNARE proteins contribute to calcium cooperativity of synaptic transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Physiologic and Nanoscale Distinctions Define Glutamatergic Synapses in Tonic vs Phasic Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- SNARE Proteins in Synaptic Vesicle Fusion.Advances in neurobiology · 2023Article
- Roles and Sources of Calcium in Synaptic Exocytosis.Advances in neurobiology · 2023Article
- SNARE Regulatory Proteins in Synaptic Vesicle Fusion and Recycling.Frontiers in molecular neuroscience · 2021Review
- Structural Predictive Model of Presenilin-2 Protein and Analysis of Structural Effects of Familial Alzheimer's Disease Mutations.Biochemistry research international · 2021Article
- CaeLife · 2019Article
- Article
- Transmission, Development, and Plasticity of Synapses.Genetics · 2015Review
- Prion protein facilitates synaptic vesicle release by enhancing release probability.Human molecular genetics · 2014Article
- The role of Drosophila cytidine monophosphate-sialic acid synthetase in the nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Functional alterations in GABAergic fast-spiking interneurons in chronically injured epileptogenic neocortex.Neurobiology of disease · 2012Article
- Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Calcium cooperativity of exocytosis as a measure of Ca²+ channel domain overlap.Brain research · 2011Review
- The role of synaptobrevin1/VAMP1 in Ca2+-triggered neurotransmitter release at the mouse neuromuscular junction.The Journal of physiology · 2011Article
- Sialyltransferase regulates nervous system function in Drosophila.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Discrete, continuous, and stochastic models of protein sorting in the Golgi apparatus.Physical review. E, Statistical, nonlinear, and soft matter physics · 2010Article
- SNAREs: cogs and coordinators in signaling and development.Plant physiology · 2008Review
- A role for soluble N-ethylmaleimide-sensitive factor attachment protein receptor complex dimerization during neurosecretion.Molecular biology of the cell · 2008Article
- Simulated de novo assembly of golgi compartments by selective cargo capture during vesicle budding and targeted vesicle fusion.Biophysical journal · 2008Article
- Ca2+-dependent, phospholipid-binding residues of synaptotagmin are critical for excitation-secretion coupling in vivo.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
A hallmark of calcium-triggered synaptic transmission is the cooperative relationship between calcium and the amount of transmitter released. This relationship is thought to be important for improving the efficiency of synaptic vesicle exocytosis. Although it is generally held that cooperativity arises from the interaction of multiple calcium ions with a single calcium-sensing molecule, the precise molecular basis of this phenomenon is not known. The SNARE proteins are known to be critical for synaptic vesicle exocytosis. We therefore tested for a contribution of SNARE proteins to cooperativity by genetically reducing the levels of syntaxin IA and neuronal-synaptobrevin in Drosophila. Surprisingly, we found that reducing these SNARE proteins also reduced Ca(2+) cooperativity. Thus, SNARE proteins are important for determining the cooperative relationship between calcium and synaptic transmission.
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