ArticleProceedings of the National Academy of Sciences of the United States of America2000
A novel type of RNA editing occurs in the mitochondrial tRNAs of the centipede Lithobius forficatus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 147 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
147 citing papers in PubMed, 342 citations in OpenAlex.
- Novel Mitogenome ofInternational journal of molecular sciences · 2026Article
- A New Taxonomic Placement ofEcology and evolution · 2026Article
- Article
- Article
- Mitogenomic Characterization ofBiology · 2025Article
- Complete mitogenomes of venomous fish Paracentropogon rubripinnis and Inimicus japonicus elucidate phylogenetic relationships in Scorpaeniformes.Scientific reports · 2025Article
- Phylogenetic Reassessment of Murinae Inferred from the Mitogenome of the Monotypic GenusBiology · 2025Article
- Comparative analysis of the mitochondrial genome of Carpodacus erythrinus (Passeriformes: Fringillidae) across different altitudes.Molecular biology reports · 2025Article
- Unusual Genetic Diversity WithinInsects · 2025Article
- Phylogenetic Relationship and Characterization of the Complete Mitochondrial Genome of the Cuckoo SpeciesInternational journal of molecular sciences · 2025Article
- Mitochondrial genomics and phylogeny of noctuoid moths: Implications for Macroheterocera.PloS one · 2025Article
- Characterization and phylogenetic implications of newly sequenced mitochondrial genomes of cobitid fish Acantopsis Rungthipae (Boyd, Nithirojpakdee & Page, 2017).Molecular biology reports · 2024Article
- Aberrant Mitochondrial tRNA Genes Appear Frequently in Animal Evolution.Genome biology and evolution · 2024Article
- The Complete Mitochondrial Genomes of Five Nivanini Species (Hemiptera: Cicadellidae: Evacanthinae) With Phylogenetic Analysis.Ecology and evolution · 2024Article
- Article
- RNA modifications in cellular metabolism: implications for metabolism-targeted therapy and immunotherapy.Signal transduction and targeted therapy · 2024Review
- Characterization of the Complete Mitochondrial Genome ofAnimals : an open access journal from MDPI · 2024Article
- Comparative Mitogenome Analyses of Fifteen Ramshorn Snails and Insights into the Phylogeny ofInternational journal of molecular sciences · 2024Article
- Comprehensive Analysis of Phylogenetic Relationship and Optimal Codons in Mitochondrial Genomes of the GenusAnimals : an open access journal from MDPI · 2024Article
- Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We determined the complete mtDNA sequence of the centipede Lithobius forficatus and found that only one of the 22 inferred tRNA genes encodes a fully paired aminoacyl acceptor stem. The other 21 genes encode tRNAs with up to five mismatches in these stems, and some of these overlap extensively with the downstream genes. Because a well-paired acceptor stem is required for proper tRNA functioning, RNA editing in the products of these genes was suspected. We investigated this hypothesis by studying cDNA sequences from eight tRNAs and found the editing of up to 5 nt at their 3' ends. This editing appears to occur by a novel mechanism with the 5' end of the acceptor stem being used as a template for the de novo synthesis of the 3' end, presumably by an RNA-dependent RNA polymerase. In addition, unusual secondary structures for several tRNAs were found, including those lacking a TPsiC (T) or a dihydrouridine (D) arm, and having an unusual number of base pairs in the acceptor or anticodon stems.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.