ArticleProceedings of the National Academy of Sciences of the United States of America2000
Identification of the residues in the Myb domain of maize C1 that specify the interaction with the bHLH cofactor R.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 166 papers.
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166 citing papers in PubMed, 350 citations in OpenAlex.
- Evolutionary and functional divergence of MYB regulatory networks in flavonoid biosynthesis across Poaceae, non-Poaceae monocots, and eudicot horticultural plants.Horticulture research · 2026Review
- A coordinated network of MYB regulators orchestrates anthocyanin biosynthesis in banana.Horticulture research · 2026Article
- Systematic characterization of the R2R3-MYB family in Lithospermum erythrorhizon and regulatory mechanisms of LeMYB1 in shikonin biosynthesis.BMC plant biology · 2026Article
- Integrated multi-omics elucidates StAN1 as a key regulator reprogramming flavonoid partitioning and co-regulatory networks in potato tubers.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- Two mutations in the same MYC-bHLH transcription factor cause segregation of purple coloration of stolons and seed heads inHorticulture research · 2025Article
- Large-scale analysis of MYB genes in Cucurbitaceae identifies a novel gene regulating plant height.Horticulture research · 2025Article
- Genetic Regulation of Anthocyanin Biosynthesis inPlant direct · 2025Article
- Potential regulation of cleistogamy in pigeonpea through jasmonic acid and bHLH transcription factor interactions.Plant reproduction · 2025Article
- Molecular insights into TT2-type MYB regulators illuminate the complexity of floral flavonoids biosynthesis inHorticulture research · 2025Article
- Regulation of Flavonoid Biosynthesis by the MYB-bHLH-WDR (MBW) Complex in Plants and Its Specific Features in Cereals.International journal of molecular sciences · 2025Review
- Genome- and Transcriptome-Wide Characterization and Expression Analyses of bHLH Transcription Factor Family Reveal Their Relevance to Salt Stress Response in Tomato.Plants (Basel, Switzerland) · 2025Article
- Proanthocyanidin biosynthesis and postharvest seed coat darkening in pinto bean.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2025Review
- Rapid recovery of homozygousFrontiers in plant science · 2025Article
- Molecular insights into postharvest seed coat darkening in common beans: a look beyond theFrontiers in plant science · 2025Article
- Article
- Evolutionary trajectory of transcription factors and selection of targets for metabolic engineering.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Genome-Wide Identification of the bHLH Gene Family inInternational journal of molecular sciences · 2024Article
- An Isoflavone Synthase Gene inPlants (Basel, Switzerland) · 2024Article
- Overexpression of a 'Plants (Basel, Switzerland) · 2024Article
- An 'activator-repressor' loop controls the anthocyanin biosynthesis in red-skinned pear.Molecular horticulture · 2024Article
106 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The maize Myb transcription factor C1 depends on the basic helix-loop-helix (bHLH) proteins R or B for regulatory function, but the closely related Myb protein P does not. We have used the similarity between the Myb domains of C1 and P to identify residues that specify the interaction between the Myb domain of C1 and the N-terminal region of R. Substitution of four predicted solvent-exposed residues in the first helix of the second Myb repeat of P with corresponding residues from C1 is sufficient to confer on P the ability to physically interact with R. However, two additional Myb domain amino acid changes are needed to make the P regulatory activity partially dependent on R in maize cells. Interestingly, when P is altered so that it interacts with R, it can activate the Bz1 promoter, normally regulated by C1 + R but not by P. Together, these findings demonstrate that the change of a few amino acids within highly similar Myb domains can mediate differential interactions with a transcriptional coregulator that plays a central role in the regulatory specificity of C1, and that Myb domains play important roles in combinatorial transcriptional regulation.
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