ArticleProceedings of the National Academy of Sciences of the United States of America2000
Enzyme mimicry by the antiidiotypic antibody approach.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 116 citations in OpenAlex.
- Anti-Idiotypic Antibodies in Immune Regulation and Disease: Therapeutic Promise for Next-Generation Vaccines.Vaccines · 2025Review
- Article
- Enzymatization of mouse monoclonal antibodies to the corresponding catalytic antibodies.Scientific reports · 2024Article
- Direct conversion of a general antibody to its catalytic antibody and corresponding applications -Importance and role of Pro95 in CDR-3.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2023Review
- A new catalytic site functioning in antigen cleavage by H34 catalytic antibody light chain.Scientific reports · 2022Article
- Nickel and Copper Catalyzed ipso-Phosphonodifluoromethylation of Arylboronic Acids with BrCFChemistry (Weinheim an der Bergstrasse, Germany) · 2022Article
- Antibodies from the Sera of Multiple Sclerosis Patients Efficiently Hydrolyze Five Histones.Biomolecules · 2019Article
- Comparison of Antibodies with Amylase Activity from Cerebrospinal Fluid and Serum of Patients with Multiple Sclerosis.PloS one · 2016Article
- DNA-hydrolysing activity of IgG antibodies from the sera of patients with schizophrenia.Open biology · 2015Article
- Comparison of antibodies hydrolyzing myelin basic protein from the cerebrospinal fluid and serum of patients with multiple sclerosis.PloS one · 2014Article
- Beyond new chemical entities: advancing drug development based on functional versatility of antibodies.Human vaccines & immunotherapeutics · 2014Article
- Comparison of DNA-hydrolyzing antibodies from the cerebrospinal fluid and serum of patients with multiple sclerosis.PloS one · 2014Article
- Biochemical features of a catalytic antibody light chain, 22F6, prepared from human lymphocytes.The Journal of biological chemistry · 2013Article
- Deoxyribonuclease activity of polyclonal IgGs: a putative serological marker in patients with spondyloarthritides.Immunologic research · 2013Article
- Chemical polysialylation of human recombinant butyrylcholinesterase delivers a long-acting bioscavenger for nerve agents in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Human milk IgGs contain various combinations of different antigen-binding sites resulting in multiple variants of their bispecificity.PloS one · 2012Article
- Article
- Affinity and catalytic heterogeneity of polyclonal myelin basic protein-hydrolyzing IgGs from sera of patients with multiple sclerosis.Journal of cellular and molecular medicine · 2010Article
- Anti-idiotypic antibodies: a new approach in prion research.BMC immunology · 2009Article
- Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The concept of "internal image" of antiidiotypic antibodies has provided the basis for eliciting catalytic antibodies. A monoclonal IgM 9A8 that was obtained as an antiidiotype to AE-2 mAb, a known inhibitor of acetylcholinesterase, displayed esterolytic activity. Study of recombinant Fab fragments and separate light and heavy chains of 9A8 confirmed that the antibody variable domain encodes the catalytic function, whereas neither part of the primary sequence of the Fab exhibited homology with the enzyme. The specific modification of the 9A8 variable domain by an active site-directed covalent inhibitor revealed the presence of an active site Ser residue. A three-dimensional modeling suggests the existence of a functional catalytic dyad Ser-His. Comparison of active sites of 9A8 and 17E8 esterolytic abzyme raised against transition-state analog revealed structural similarity although both antibodies were elicited by two different approaches.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.