ArticleNucleic acids research2000
Enhanced flexibility and aphidicolin-induced DNA breaks near mammalian replication origins: implications for replicon mapping and chromosome fragility.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage.Cell death & disease · 2025Article
- Genomic hotspots of chromosome rearrangements explain conserved synteny despite high rates of chromosome evolution in a holocentric lineage.Molecular ecology · 2024Article
- High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.Cell research · 2020Article
- The role of fork stalling and DNA structures in causing chromosome fragility.Genes, chromosomes & cancer · 2019Review
- Decondensation of chromosomal 45S rDNA sites in Lolium and Festuca genotypes does not result in karyotype instability.Protoplasma · 2017Article
- Article
- Plant 45S rDNA clusters are fragile sites and their instability is associated with epigenetic alterations.PloS one · 2012Article
- Impaired replication dynamics at the FRA3B common fragile site.Human molecular genetics · 2010Article
- Common fragile sites are characterized by histone hypoacetylation.Human molecular genetics · 2009Article
- Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study.Oncogene · 2008Article
- High-resolution mapping identifies a commonly amplified 11q13.3 region containing multiple genes flanked by segmental duplications.Human genetics · 2007Article
- Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents.Oncogene · 2004Article
- Enhanced expression of MYCN leads to centrosome hyperamplification after DNA damage in neuroblastoma cells.Oncogene · 2004Article
- Matrix attachment region (MAR) properties and abnormal expansion of AT island minisatellites in FRA16B fragile sites in leukemic CEM cells.Nucleic acids research · 2003Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Common fragile sites are chromosomal loci prone to breakage and rearrangement that can be induced by aphidicolin, an inhibitor of DNA polymerases. Within these loci, sites of preferential DNA breaks were proposed to correlate with peaks of enhanced DNA flexibility, the function of which remains elusive. Here we show that mammalian DNA replication origins are enriched in peaks of enhanced flexibility. This finding suggests that the search for these features may help in the mapping of replication origins, and we present evidence supporting this hypothesis. The association of peaks of flexibility with replication origins also suggests that some origins may associate with minor levels of fragility. As shown here, an increased sensitivity to aphidicolin was found near two mammalian DNA replication origins.
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