ArticleNucleic acids research2000
Cis-acting influences on Alu RNA levels.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- The angiotensin-I-converting enzyme insertion/deletion in polymorphic element codes for an AluYa5 RNA that downregulates gene expression.The pharmacogenomics journal · 2018Review
- Mechanism by which a LINE protein recognizes its 3' tail RNA.Nucleic acids research · 2014Article
- Molecular reconstruction of extinct LINE-1 elements and their interaction with nonautonomous elements.Molecular biology and evolution · 2013Article
- Impact of retrotransposons in pluripotent stem cells.Molecules and cells · 2012Review
- Human transposon tectonics.Cell · 2012Review
- Structure of noncoding RNA is a determinant of function of RNA binding proteins in transcriptional regulation.Cell & bioscience · 2012Article
- Restless genomes humans as a model organism for understanding host-retrotransposable element dynamics.Advances in genetics · 2011Review
- Epigenetic control of retrotransposon expression in human embryonic stem cells.Molecular and cellular biology · 2011Article
- Genomic gems: SINE RNAs regulate mRNA production.Current opinion in genetics & development · 2010Review
- Alu-directed transcriptional regulation of some novel miRNAs.BMC genomics · 2009Article
- The impact of retrotransposons on human genome evolution.Nature reviews. Genetics · 2009Review
- Review
- Diverse cis factors controlling Alu retrotransposition: what causes Alu elements to die?Genome research · 2009Article
- Evolution and distribution of RNA polymerase II regulatory sites from RNA polymerase III dependant mobile Alu elements.BMC evolutionary biology · 2004Article
- Synthesis and processing of tRNA-related SINE transcripts in Arabidopsis thaliana.Nucleic acids research · 2004Article
- Potential for retroposition by old Alu subfamilies.Journal of molecular evolution · 2003Article
- Active Alu element "A-tails": size does matter.Genome research · 2002Article
- Recent publications by ochsner authors.Ochsner journal · 2002Article
- Recent publications by ochsner authors.Ochsner journal · 2002Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The human short interspersed repeated element (SINE), Alu, amplifies through a poorly understood RNA-mediated mechanism, termed retroposition. There are over one million copies of Alu per haploid human genome. The copies show some internal variations in sequence and are very heterogeneous in chromosomal environment. However, very few Alu elements actively amplify. The amplification rate has decreased greatly in the last 40 million years. Factors influencing Alu transcription would directly affect an element's retroposition capability. Therefore, we evaluated several features that might influence expression from individual Alu elements. The influence of various internal sequence variations and 3' unique flanks on full-length Alu RNA steady-state levels was determined. Alu subfamily diagnostic mutations do not significantly alter the amount of Alu RNA observed. However, sequences containing random mutations throughout the right half of selected genomic Alu elements altered Alu RNA steady-state levels in cultured cells. In addition, sequence variations at the 3' unique end of the transcript also significantly altered the Alu RNA levels. In general, sequence mutations and 3' end sequences contribute to Alu RNA levels, suggesting that the master Alu element(s) have a multitude of individual differences that collectively gives them a selective advantage over other Alu elements.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.