Evidence map›Paper›PMID 11095680›Full record

ArticleNucleic acids research2000

Comparative analysis of more than 3000 sequences reveals the existence of two pseudoknots in area V4 of eukaryotic small subunit ribosomal RNA.

J Wuyts, P De Rijk, Y Van de Peer, G Pison, P Rousseeuw, R De Wachter

Abstract readComparative Study
In one paragraph

Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
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  8. Protists Within Corals: The Hidden Diversity.Frontiers in microbiology · 2018
    Article
  9. Cryptic infection of a broad taxonomic and geographic diversity of tadpoles by Perkinsea protists.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

J WuytsDepartement Biochemie, Universiteit Antwerpen (UIA), Universiteitsplein 1, B 2610 Antwerpen, Belgium.
P De Rijk
Y Van de Peer
G Pison
P Rousseeuw
R De Wachter

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The secondary structure of V4, the largest variable area of eukaryotic small subunit ribosomal RNA, was re-examined by comparative analysis of 3253 nucleotide sequences distributed over the animal, plant and fungal kingdoms and a diverse set of protist taxa. An extensive search for compensating base pair substitutions and for base covariation revealed that in most eukaryotes the secondary structure of the area consists of 11 helices and includes two pseudoknots. In one of the pseudoknots, exchange of base pairs between the two stems seems to occur, and covariation analysis points to the presence of a base triple. The area also contains three potential insertion points where additional hairpins or branched structures are present in a number of taxa scattered throughout the eukaryotic domain.

Indexed as

Nucleic Acid ConformationBase SequenceEukaryotic CellsModels, MolecularMolecular Sequence DataMolecular StructureRNA, RibosomalSequence Homology, Nucleic AcidSpecies SpecificityRNA, Ribosomal

Identifiers

PMID11095680
PMCPMC115172

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.