ReviewArthritis research2000
Bone loss. Factors that regulate osteoclast differentiation: an update.
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 195 citations in OpenAlex.
- Bone mineral density in patients with early rheumatoid arthritis treated with corticosteroids.Clinical rheumatology · 2005Trial
- Buccal Bone Wall Thickness Dictates the Extent of Vertical Buccal Bone Loss Following Implant Placement: A Preclinical Study.Journal of clinical periodontology · 2025Article
- Research Trends in Immunomodulatory Therapy for Postmenopausal Osteoporosis: A Bibliometric Analysis.Orthopaedic surgery · 2025Review
- Blockade of IL-1 family cytokines in the treatment of rheumatoid arthritis.Frontiers in pharmacology · 2025Review
- Differential but complementary roles of HIF-1α and HIF-2α in the regulation of bone homeostasis.Communications biology · 2024Article
- The Impact of Tannic Acid Consumption on Bone Mineralization.Metabolites · 2023Review
- CircZNF367 promotes osteoclast differentiation and osteoporosis by interacting with FUS to maintain CRY2 mRNA stability.Journal of orthopaedic surgery and research · 2023Article
- A Review on Pathophysiology, and Molecular Mechanisms of Bacterial Chondronecrosis and Osteomyelitis in Commercial Broilers.Biomolecules · 2023Review
- Macropore Regulation of Hydroxyapatite Osteoinduction via Microfluidic Pathway.International journal of molecular sciences · 2022Article
- Biomarkers mining for spinal cord injury based on integrated multi-transcriptome expression profile data.Journal of orthopaedic surgery and research · 2021Article
- The Effect of Inflammation on Bone.Frontiers in physiology · 2020Review
- Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration.Aging and disease · 2019Article
- Eimeria challenge adversely affected long bone attributes linked to increased resorption in 14-day-old broiler chickens.Poultry science · 2019Article
- Understanding Peri-Implantitis as a Plaque-Associated and Site-Specific Entity: On the Local Predisposing Factors.Journal of clinical medicine · 2019Review
- Article
- Characteristics of wear particles and wear behavior of retrieved PEEK-on-HXLPE total knee implants: a preliminary study.RSC advances · 2018Article
- Effects of denosumab on bone metabolism and bone mineral density with anti-TNF inhibitors, tocilizumab, or abatacept in osteoporosis with rheumatoid arthritis.Therapeutics and clinical risk management · 2018Article
- Revisiting the role of testosterone: Are we missing something?Reviews in urology · 2017Article
- Ectopic osteogenesis and angiogenesis regulated by porous architecture of hydroxyapatite scaffolds with similar interconnecting structure in vivo.Regenerative biomaterials · 2016Article
- Nutritional Strategies in the Management of Adult Patients with Inflammatory Bowel Disease: Dietary Considerations from Active Disease to Disease Remission.Current gastroenterology reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoclast activation is a critical cellular process for pathological bone resorption, such as erosions in rheumatoid arthritis (RA) or generalized bone loss. Among many factors triggering excessive osteoclast activity, cytokines such as IL-1 or tumour necrosis factor (TNF)-alpha play a central role. New members of the TNF receptor ligand family (namely receptor activator of nuclear factor-kappa B [RANK] and RANK ligand [RANKL]) have been discovered whose cross-interaction is mandatory for the differentiation of osteoclasts from hemopoietic precursors, in both physiological and pathological situations. Osteoprotegerin, a decoy receptor which blocks this interaction, decreases osteoclast activity and could have a fascinating therapeutic potential in conditions associated with upregulated bone resorption.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.