ReviewArthritis research2000
Insights into rheumatoid arthritis derived from the Sa immune system.
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed.
- Intersection Between Large Granular Lymphocyte Leukemia and Rheumatoid Arthritis.Frontiers in oncology · 2022Review
- Evaluation of autoantibodies against vimentin and α-enolase in rheumatoid arthritis patients.Reumatologia · 2020Article
- Insights of rheumatoid arthritis risk factors and associations.Journal of translational autoimmunity · 2019Review
- Autoantibodies as Diagnostic Markers and Mediator of Joint Inflammation in Arthritis.Mediators of inflammation · 2019Review
- Biomarkers in connective tissue diseases.The Journal of allergy and clinical immunology · 2017Review
- Dendritic cells and isolevuglandins in immunity, inflammation, and hypertension.American journal of physiology. Heart and circulatory physiology · 2017Review
- The Autophagy Level Is Increased in the Synovial Tissues of Patients with Active Rheumatoid Arthritis and Is Correlated with Disease Severity.Mediators of inflammation · 2017Article
- A Contra Capture Protein Array Platform for Studying Post-translationally Modified (PTM) Auto-antigenomes.Molecular & cellular proteomics : MCP · 2016Article
- Immune activation caused by vascular oxidation promotes fibrosis and hypertension.The Journal of clinical investigation · 2016Article
- Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design.ACS chemical biology · 2015Article
- Higher levels of autoantibodies targeting mutated citrullinated vimentin in patients with psoriatic arthritis than in patients with psoriasis vulgaris.Clinical & developmental immunology · 2013Article
- Candidate autoantigens identified by mass spectrometry in early rheumatoid arthritis are chaperones and citrullinated glycolytic enzymes.Arthritis research & therapy · 2009Article
- Arthritis induced by posttranslationally modified (citrullinated) fibrinogen in DR4-IE transgenic mice.The Journal of experimental medicine · 2008Article
- Rheumatoid factors and anticyclic citrullinated peptide antibodies in pediatric rheumatology.Current rheumatology reports · 2008Review
- Anti-citrullinated protein antibodies in rheumatoid arthritis: as good as it gets?Clinical reviews in allergy & immunology · 2008Review
- Antibodies to citrullinated vimentin are a specific and sensitive marker for the diagnosis of rheumatoid arthritis.Clinical reviews in allergy & immunology · 2008Article
- The immune response to citrullinated proteins in patients with rheumatoid arthritis: genetic, clinical, technical, and epidemiological aspects.Clinical reviews in allergy & immunology · 2007Review
- Diagnostic value of antibodies against a modified citrullinated vimentin in rheumatoid arthritis.Arthritis research & therapy · 2006Article
- Amplification of autoimmune disease by infection.Arthritis research & therapy · 2005Review
- Anti-CCP antibody test predicts the disease course during 3 years in early rheumatoid arthritis (the Swedish TIRA project).Annals of the rheumatic diseases · 2004Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Sa system is a recently described immune system that has a specificity and positive predictive value of nearly 100% for rheumatoid arthritis (RA) in Asia, Europe and the Americas. Its sensitivity of 30-40% suggests that it identifies a subset of RA patients. Anti-Sa antibodies are present from disease onset and are predictive of disease severity. The immune reactants are plentiful in the target tissue: antigen is present in the synovium, IgG antibody in the fluid. Immunologically, Sa is a hapten-carrier antigen in which vimentin is the carrier and citrulline is the hapten. The citrullination of vimentin is closely related to apoptosis, and citrullinated vimentin is extremely sensitive to digestion by the ubiquitous calpains. Nevertheless, Sa is found in only a few cell lines. Calpastatin, the natural specific inhibitor of calpains, is also a RA-associated, albeit non-specific, autoimmune system. Is it possible that calpain-related apoptotic pathways could be prominent in cells containing Sa? The task is to reconcile the specificity of Sa/citrullinated proteins in a multifactorial and polygenic disease such as RA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.