ReviewArthritis research2000
Association of MHC and rheumatoid arthritis. Association of RA with HLA-DR4: the role of repertoire selection.
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 66 citations in OpenAlex.
- Use of Artificial Intelligence in Rheumatoid Arthritis: Advancements and Novel Perspectives.Journal of clinical medicine · 2026Review
- Association of HLA-A*02:01 type with efficacy and toxicity of immune checkpoint inhibitor therapy in melanoma patients: a retrospective cohort study.BMC cancer · 2025Article
- Genetic testing and human leukocyte antigen in patients with hypertrophic cardiomyopathy and connective tissue diseases.Frontiers in genetics · 2024Article
- Human MHC-II with Shared Epitope Motifs Are Optimal Epstein-Barr Virus Glycoprotein 42 Ligands-Relation to Rheumatoid Arthritis.International journal of molecular sciences · 2018Review
- Article
- Genetic variation in MHC proteins is associated with T cell receptor expression biases.Nature genetics · 2016Article
- Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism.Journal of human genetics · 2015Review
- Expanded dog leukocyte antigen (DLA) single nucleotide polymorphism (SNP) genotyping reveals spurious class II associations.Veterinary journal (London, England : 1997) · 2011Article
- Hypertrophic obstructive cardiomyopathy in rheumatoid arthtritis - coincidence or association? A case report.Experimental and clinical cardiology · 2009Article
- Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their first-degree relatives.Journal of autoimmunity · 2008Article
- Anti-citrullinated protein antibodies in rheumatoid arthritis: as good as it gets?Clinical reviews in allergy & immunology · 2008Review
- MHC class II derived recombinant T cell receptor ligands protect DBA/1LacJ mice from collagen-induced arthritis.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Interleukin-7 induced immunopathology in arthritis.Annals of the rheumatic diseases · 2006Review
- Host genetic determinants in hepatitis C virus infection.Genes and immunity · 2004Review
- Human leukocyte antigen distribution in Israeli patients with psoriatic arthritis.Rheumatology international · 2004Article
- Association of MHC and rheumatoid arthritis. Why is rheumatoid arthritis associated with the MHC genetic region? An introduction.Arthritis research · 2000Review
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most patients with rheumatoid arthritis (RA) express HLA-DR4, HLA-DR1 or HLA-DR10. These alleles share a common amino acid motif in their third hypervariable regions: the shared epitope. In normals and patients with RA, HLA-DR genes exert a major influence on the CD4 alpha beta T-cell repertoire, as shown by studies of AV and BV gene usage and by BV BJ gene usage by peripheral blood CD4 alpha beta T-cells. However, the rheumatoid T-cell repertoire is not entirely under HLA-DR influence, as demonstrated by discrepancies in VB JB gene usage between identical twins discordant for RA and by contraction of the CD4 alpha beta T-cell repertoire in RA patients. Shared epitope positive HLA-DR alleles may shape the T-cell repertoire by presenting self peptides to CD4 T cells in the thymus. Peptides processed from HLA-DR molecules and encompassing the shared epitope may also be presented by HLA-DQ and select CD4 alpha beta T cells in the thymus. Thus, shared epitope-positive alleles impose a frame on the T-cell repertoire. This predisposing frame is further modified (by unknown factors) to obtain the contracted rheumatoid repertoire.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.