ReviewArthritis research2000
B cells in rheumatoid arthritis.
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed.
- Fc-enhanced anti-CCR6 antibody elicits robust therapeutic effects across multiple autoimmune diseases.Frontiers in immunology · 2025Article
- Engineering approaches to investigate the roles of lymphatics vessels in rheumatoid arthritis.Microcirculation (New York, N.Y. : 1994) · 2023Review
- Heterogeneity of antibody-secreting cells infiltrating autoimmune tissues.Frontiers in immunology · 2023Review
- Activation of formyl peptide receptor 1 elicits therapeutic effects against collagen-induced arthritis.Journal of cellular and molecular medicine · 2021Article
- B cells expressing the IgA receptor FcRL4 participate in the autoimmune response in patients with rheumatoid arthritis.Journal of autoimmunity · 2017Article
- Integrating B cell lineage information into statistical tests for detecting selection in Ig sequences.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Inflammation and rheumatoid arthritis.Journal of physiology and biochemistry · 2013Review
- Roles of γδ T cells in the pathogenesis of autoimmune diseases.Clinical & developmental immunology · 2013Review
- Selective inhibitors of phosphoinositide 3-kinase delta: modulators of B-cell function with potential for treating autoimmune inflammatory diseases and B-cell malignancies.Frontiers in immunology · 2012Article
- Current imaging strategies in rheumatoid arthritis.American journal of nuclear medicine and molecular imaging · 2012Article
- Manifestation of spontaneous and early autoimmune gastritis in CCR7-deficient mice.The American journal of pathology · 2011Article
- Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunities.The American journal of pathology · 2011Review
- Clinical consequences of defects in B-cell development.The Journal of allergy and clinical immunology · 2010Review
- Circulating CD21low B cells in common variable immunodeficiency resemble tissue homing, innate-like B cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Article
- Intra-articular vs. systemic administration of etanercept in antigen-induced arthritis in the temporomandibular point. Part I: histological effects.Pediatric rheumatology online journal · 2009Article
- Chemokine receptor expression and functional effects of chemokines on B cells: implication in the pathogenesis of rheumatoid arthritis.Arthritis research & therapy · 2009Article
- Rituximab therapy in Greek patients with rheumatoid arthritis.Biologics : targets & therapy · 2008Article
- Frequency of regulatory T cells is not affected by transient B cell depletion using anti-CD20 antibodies in rheumatoid arthritis.The open rheumatology journal · 2008Article
- Abrogation of lupus nephritis in activation-induced deaminase-deficient MRL/lpr mice.Journal of immunology (Baltimore, Md. : 1950) · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Normally the immune response is restricted to the peripheral secondary lymphoid organs. However, additional ectopic lymphoid tissue may develop at chronic sites of inflammation. In the synovium of rheumatoid arthritis patients the local production of proinflammatory cytokines seems to support the formation of a precisely structured microenvironment, which allows an antigen dependent immune response to take place. The analysis of the V-gene repertoire expressed in synovial B cells demonstrated that in the inflamed synovium a germinal centre reaction takes place. Antigen presented by a network of follicular dendritic cells may activate synovial B cells and support their differentiation into plasma cells secreting high affinity antibodies. The specificity of these antibodies remains to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.