ReviewArthritis research2000
What can we do about osteoarthritis?
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Molecular Mechanisms and Therapeutic Role of Intra-Articular Hyaluronic Acid in Osteoarthritis: A Precision Medicine Perspective.Journal of clinical medicine · 2025Review
- Non-linear associations between blood glucose, blood lipids and inflammatory markers and new-onset arthritis in the middle-aged and older population - a cohort study in Europe.Lipids in health and disease · 2025Article
- Intra-Articular Hyaluronic Acid for Knee Osteoarthritis: A Systematic Umbrella Review.Journal of clinical medicine · 2025Review
- Arthritis prevalence is associated with metabolic syndrome risk factors but not with physical activity in middle-aged and older patients - a cross-sectional study.BMC geriatrics · 2024Article
- Effects of a Combination of Polynucleotide and Hyaluronic Acid for Treating Osteoarthritis.International journal of molecular sciences · 2024Article
- Prediction and analysis of osteoarthritis hub genes with bioinformatics.Annals of translational medicine · 2023Article
- A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model.Biomaterials · 2018Article
- In Vitro and In Vivo Anti-Osteoarthritis Effects of 2,3,5,4'-Tetrahydroxystilbene-2-O-β-d-Glucoside from Polygonum Multiflorum.Molecules (Basel, Switzerland) · 2018Article
- Synthesis and Preclinical Characterization of a Cationic Iodinated Imaging Contrast Agent (CA4+) and Its Use for Quantitative Computed Tomography of Ex Vivo Human Hip Cartilage.Journal of medicinal chemistry · 2017Article
- Expression and pathological effects of periostin in human osteoarthritis cartilage.BMC musculoskeletal disorders · 2015Article
- Intra-articular zoledronic acid in a rat osteoarthritis model: significant reduced synovitis may indicate chondroprotective effect.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2015Article
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- Cationic agent contrast-enhanced computed tomography imaging of cartilage correlates with the compressive modulus and coefficient of friction.Osteoarthritis and cartilage · 2013Article
- Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray.PloS one · 2012Article
- Molecular changes in articular cartilage and subchondral bone in the rat anterior cruciate ligament transection and meniscectomized models of osteoarthritis.BMC musculoskeletal disorders · 2011Article
- Cartilage-selective genes identified in genome-scale analysis of non-cartilage and cartilage gene expression.BMC genomics · 2007Article
- The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta.BMC complementary and alternative medicine · 2006Article
- Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711].Journal of inflammation (London, England) · 2005Article
- Disease-modifying therapies for osteoarthritis : current status.Drugs & aging · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osteoarthritis is complex in genetics, pathogenesis, monitoring and treatment. Current treatment of osteoarthritis does not influence progression. Much could be gained by more effective 'low-tech-low-cost' treatment. However, many patients have rapidly progressive disease, multiple joint involvement, and severe disease. We need to clarify the genetics of osteoarthritis, identify those at risk for progression and severe disease, and identify molecular processes critical for joint survival and failure. Will saving the cartilage improve patient pain and function? Effective outcome measures are needed to accelerate testing of new treatments. Further improvement is needed in joint implant technology to decrease costs, wear and loosening.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.