ReviewArthritis research2000
A revival of the B cell paradigm for rheumatoid arthritis pathogenesis?
Review in Arthritis research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 50 citations in OpenAlex.
- Intravenous Immunoglobulin Controls Th17 Cell-Mediated Osteoclastogenesis.Immune network · 2019Article
- The human complement receptor type 2 (CR2)/CR1 fusion protein TT32, a novel targeted inhibitor of the classical and alternative pathway C3 convertases, prevents arthritis in active immunization and passive transfer mouse models.Molecular immunology · 2019Article
- The Therapeutic Potential for PI3K Inhibitors in Autoimmune Rheumatic Diseases.The open rheumatology journal · 2012Article
- Cytokine-dependent but acquired immunity-independent arthritis caused by DNA escaped from degradation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- IL-17-producing T cells can augment autoantibody-induced arthritis.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Rituximab therapy in Greek patients with rheumatoid arthritis.Biologics : targets & therapy · 2008Article
- Fundamental differences in the dynamics of CNS lesion development and composition in MP4- and MOG peptide 35-55-induced experimental autoimmune encephalomyelitis.Clinical immunology (Orlando, Fla.) · 2008Article
- Apoptotic cells protect mice from autoimmune inflammation by the induction of regulatory B cells.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- In vivo expression pattern of MICA and MICB and its relevance to auto-immunity and cancer.PloS one · 2007Article
- Auto-antibodies and autoreactive T-cells in rheumatoid arthritis: pathogenetic players and diagnostic tools.Clinical reviews in allergy & immunology · 2007Review
- The complex role of Fcgamma receptors in the pathology of arthritis.Springer seminars in immunopathology · 2006Review
- Clinical, laboratory and genetic markers associated with erosions and remission in patients with early inflammatory arthritis: a prospective cohort study.Rheumatology international · 2006Article
- Direct interaction of immunoglobulins with synovial fibroblasts: a missing link in the pathogenesis of rheumatoid arthritis?Arthritis research & therapy · 2005Article
- Modulating co-stimulation: a rational strategy in the treatment of rheumatoid arthritis?Arthritis research & therapy · 2005Review
- The inhibitory co-receptor, PECAM-1 provides a protective effect in suppression of collagen-induced arthritis.Journal of clinical immunology · 2005Article
- The MHC class I-like Fc receptor promotes humorally mediated autoimmune disease.The Journal of clinical investigation · 2004Article
- Role of RANKL and RANK in bone loss and arthritis.Annals of the rheumatic diseases · 2002Review
- Lessons from animal models of arthritis.Current rheumatology reports · 2002Review
- p53 in rheumatoid arthritis: friend or foe?Arthritis research · 2000Review
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dominant paradigms for the understanding of rheumatoid arthritis (RA) pathogenesis have changed over the years. A predominant role of B lymphocytes, and perhaps of the rheumatoid factor they produced, was initially invoked. In more recent years, recognition of antigens in the joint by T cells sparking an inflammatory cascade has been a more favored interpretation. Here, we re-examine some of the arguments that underpin this proposed role of joint T cells, in light of recent results from transgenic mice in which a self-reactive T-cell receptor provokes disease, but from outside the joint and indirectly via B lymphocytes and immunoglobulins.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.