ReviewArthritis research1999
Genetics of rheumatoid arthritis: confronting complexity.
Review in Arthritis research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- The current status of anti-citrullinated protein antibodies and citrullinated protein-reactive B cells in the pathogenesis of rheumatoid arthritis.Molecular biology reports · 2022Review
- A 9 mRNAs-based diagnostic signature for rheumatoid arthritis by integrating bioinformatic analysis and machine-learning.Journal of orthopaedic surgery and research · 2021Article
- Biomarkers to Personalize the Treatment of Rheumatoid Arthritis: Focus on Autoantibodies and Pharmacogenetics.Biomolecules · 2020Review
- Review
- The Association of the GABRP Polymorphisms with Systemic Lupus Erythematosus.Journal of immunology research · 2015Article
- Polymorphisms of interleukin-31 are associated with anti-CCP levels in females with rheumatoid arthritis.Journal of genetics · 2014Article
- A powerful approach for association analysis incorporating imprinting effects.Bioinformatics (Oxford, England) · 2011Article
- Toll-like receptors are potential therapeutic targets in rheumatoid arthritis.World journal of biological chemistry · 2011Article
- Proteoglycan-induced arthritis and recombinant human proteoglycan aggrecan G1 domain-induced arthritis in BALB/c mice resembling two subtypes of rheumatoid arthritis.Arthritis and rheumatism · 2011Article
- Article
- Identification of correlated genetic variants jointly associated with rheumatoid arthritis using ridge regression.BMC proceedings · 2009Article
- Polymorphisms of COTL1 gene identified by proteomic approach and their association with autoimmune disorders.Experimental & molecular medicine · 2009Article
- Association of TBX21 polymorphisms in a Korean population with rheumatoid arthritis.Experimental & molecular medicine · 2009Article
- BALB/c mice genetically susceptible to proteoglycan-induced arthritis and spondylitis show colony-dependent differences in disease penetrance.Arthritis research & therapy · 2009Article
- Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Indian herbal medicines: possible potent therapeutic agents for rheumatoid arthritis.Journal of clinical biochemistry and nutrition · 2007Article
- Comparison of genome-wide single-nucleotide polymorphism linkage analyses in Caucasian and Hispanic NARAC families.BMC proceedings · 2007Article
- Classification of rheumatoid arthritis status with candidate gene and genome-wide single-nucleotide polymorphisms using random forests.BMC proceedings · 2007Article
- High-density SNP analysis of 642 Caucasian families with rheumatoid arthritis identifies two new linkage regions on 11p12 and 2q33.Genes and immunity · 2006Article
- The polymorphisms of Tim-1 promoter region are associated with rheumatoid arthritis in a Korean population.Immunogenetics · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
The genetic basis for rheumatoid arthritis (RA) is likely to be extremely complex. Even the role of MHC genes remains to be fully defined, and may involve interactive genetic effects. The difficulty of precisely defining the clinical phenotype, as well as underlying genetic heterogeneity, complicates the problem. In addition, stochastic genetic or physiologic events may contribute to the low penetrance of susceptibility genes. This situation parallels developing paradigms for other autoimmune disorders, in which many different genes each appear to contribute a small amount to overall risk for disease, and where severity and specific phenotypic subtypes are subject to genetic effects. The completion of the human genome project, along with advances in informatics, will be required to reach a deeper understanding of RA. It is likely that this will involve an iterative and interactive process between several different scientific disciplines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.