ArticleMolecular and cellular biology2000
Retinoblastoma protein disrupts interactions required for RNA polymerase III transcription.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 78 citations in OpenAlex.
- Article
- tRNA dysregulation and disease.Nature reviews. Genetics · 2022Review
- Article
- The genomic loci of specific human tRNA genes exhibit ageing-related DNA hypermethylation.Nature communications · 2021Article
- RNF12 catalyzes BRF1 ubiquitination and regulates RNA polymerase III-dependent transcription.The Journal of biological chemistry · 2019Article
- Ribosomal proteins: insight into molecular roles and functions in hepatocellular carcinoma.Oncogene · 2018Review
- Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.Liver research (Beijing, China) · 2017Article
- Transcription by RNA polymerase III: insights into mechanism and regulation.Biochemical Society transactions · 2016Review
- Ribosomal proteins: functions beyond the ribosome.Journal of molecular cell biology · 2015Review
- SINE transcription by RNA polymerase III is suppressed by histone methylation but not by DNA methylation.Nature communications · 2015Article
- An HDAC inhibitor enhances cancer therapeutic efficiency of RNA polymerase III promoter-driven IDO shRNA.Cancer gene therapy · 2013Article
- Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.The Journal of biological chemistry · 2012Article
- Transcription by RNA polymerase III: more complex than we thought.Nature reviews. Genetics · 2011Review
- RNA polymerase III transcription in cancer: the BRF2 connection.Molecular cancer · 2011Review
- Transcriptional repression: conserved and evolved features.Current biology : CB · 2010Review
- Genomic binding profiles of functionally distinct RNA polymerase III transcription complexes in human cells.Nature structural & molecular biology · 2010Article
- Regulation of TFIIIB during F9 cell differentiation.BMC molecular biology · 2010Article
- TLS inhibits RNA polymerase III transcription.Molecular and cellular biology · 2010Article
- Down-regulation of the transcriptional mediator subunit Med1 contributes to the loss of expression of metastasis-associated dapk1 in human cancers and cancer cells.International journal of cancer · 2009Article
- The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The retinoblastoma protein (RB) has been shown to suppress RNA polymerase (Pol) III transcription in vivo (R. J. White, D. Trouche, K. Martin, S. P. Jackson, and T. Kouzarides, Nature 382:88-90, 1996). This regulation involves interaction with TFIIIB, a multisubunit factor that is required for the expression of all Pol III templates (C. G. C. Larminie, C. A. Cairns, R. Mital, K. Martin, T. Kouzarides, S. P. Jackson, and R. J. White, EMBO J. 16:2061-2071, 1997; W.-M. Chu, Z. Wang, R. G. Roeder, and C. W. Schmid, J. Biol. Chem. 272:14755-14761, 1997). However, it has not been established why RB binding to TFIIIB results in transcriptional repression. For several Pol II-transcribed genes, RB has been shown to inhibit expression by recruiting histone deacetylases, which are thought to decrease promoter accessibility. We present evidence that histone deacetylases exert a negative effect on Pol III activity in vivo. However, RB remains able to regulate Pol III transcription in the presence of the histone deacetylase inhibitor trichostatin A. Instead, RB represses by disrupting interactions between TFIIIB and other components of the basal Pol III transcription apparatus. Recruitment of TFIIIB to most class III genes requires its binding to TFIIIC2, but this can be blocked by RB. In addition, RB disrupts the interaction between TFIIIB and Pol III that is essential for transcription. The ability of RB to inhibit these key interactions can explain its action as a potent repressor of class III gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.