ArticleMolecular and cellular biology2000
The retinoblastoma tumor suppressor protein targets distinct general transcription factors to regulate RNA polymerase III gene expression.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- Article
- tRNA dysregulation and disease.Nature reviews. Genetics · 2022Review
- Eag1 Gene and Protein Expression in Human Retinoblastoma Tumors and its Regulation by pRb in HeLa Cells.Genes · 2020Article
- Genome-Wide Analysis of Drosophila RBf2 Protein Highlights the Diversity of RB Family Targets and Possible Role in Regulation of Ribosome Biosynthesis.G3 (Bethesda, Md.) · 2015Article
- Requirement for SNAPC1 in transcriptional responsiveness to diverse extracellular signals.Molecular and cellular biology · 2012Article
- Regulation of human RNA polymerase III transcription by DNMT1 and DNMT3a DNA methyltransferases.The Journal of biological chemistry · 2012Article
- RNA polymerase III transcription in cancer: the BRF2 connection.Molecular cancer · 2011Review
- TLS inhibits RNA polymerase III transcription.Molecular and cellular biology · 2010Article
- Transcriptional regulation of human small nuclear RNA genes.Biochimica et biophysica acta · 2008Review
- The nanovirus-encoded Clink protein affects plant cell cycle regulation through interaction with the retinoblastoma-related protein.Journal of virology · 2007Article
- Retinoblastoma protein regulation by the COP9 signalosome.Molecular biology of the cell · 2007Article
- Article
- Co-expression of multiple subunits enables recombinant SNAPC assembly and function for transcription by human RNA polymerases II and III.Protein expression and purification · 2006Article
- Hypoxic stress suppresses RNA polymerase III recruitment and tRNA gene transcription in cardiomyocytes.Nucleic acids research · 2006Article
- Distinct mechanisms for repression of RNA polymerase III transcription by the retinoblastoma tumor suppressor protein.Molecular and cellular biology · 2004Article
- RNA polymerase III transcription and cancer.Oncogene · 2004Review
- RNA polymerase III repression by the retinoblastoma tumor suppressor protein.Biochimica et biophysica actaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The retinoblastoma protein (RB) represses RNA polymerase III transcription effectively both in vivo and in vitro. Here we demonstrate that the general transcription factors snRNA-activating protein complex (SNAP(c)) and TATA binding protein (TBP) are important for RB repression of human U6 snRNA gene transcription by RNA polymerase III. RB is associated with SNAP(c) as detected by both coimmunoprecipitation of endogenous RB with SNAP(c) and cofractionation of RB and SNAP(c) during chromatographic purification. RB also interacts with two SNAP(c) subunits, SNAP43 and SNAP50. TBP or a combination of TBP and SNAP(c) restores efficient U6 transcription from RB-treated extracts, indicating that TBP is also involved in RB regulation. In contrast, the TBP-containing complex TFIIIB restores adenovirus VAI but not human U6 transcription in RB-treated extracts, suggesting that TFIIIB is important for RB regulation of tRNA-like genes. These results suggest that different classes of RNA polymerase III-transcribed genes have distinct general transcription factor requirements for repression by RB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.