ArticleJapanese journal of cancer research : Gann2000
A novel "Nihon" rat model of a Mendelian dominantly inherited renal cell carcinoma.
Article in Japanese journal of cancer research : Gann, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 35 citations in OpenAlex.
- Choosing The Right Animal Model for Renal Cancer Research.Translational oncology · 2020Review
- Spontaneous renal tumors suspected of being familial in sprague-dawley rats.Journal of toxicologic pathology · 2012Article
- Cystic cholangioma in the thoracic cavity of a rat.Journal of toxicologic pathology · 2012Article
- Orthotopic xenografts of RCC retain histological, immunophenotypic and genetic features of tumours in patients.The Journal of pathology · 2011Article
- The folliculin mutation database: an online database of mutations associated with Birt-Hogg-Dubé syndrome.Human mutation · 2009Article
- Interaction of folliculin (Birt-Hogg-Dubé gene product) with a novel Fnip1-like (FnipL/Fnip2) protein.Oncogene · 2008Article
- BHD mutations, clinical and molecular genetic investigations of Birt-Hogg-Dubé syndrome: a new series of 50 families and a review of published reports.Journal of medical genetics · 2008Review
- Spontaneous occurrence of a distinctive renal tubule tumor phenotype in rat carcinogenicity studies conducted by the national toxicology program.Toxicologic pathology · 2008Article
- Transgenic rescue from embryonic lethality and renal carcinogenesis in the Nihon rat model by introduction of a wild-type Bhd gene.Oncogene · 2006Article
- Natural history of the Nihon (Bhd gene mutant) rat, a novel model for human Birt-Hogg-Dubé syndrome.Virchows Archiv : an international journal of pathology · 2006Article
- Germline BHD-mutation spectrum and phenotype analysis of a large cohort of families with Birt-Hogg-Dubé syndrome.American journal of human genetics · 2005Article
- Niban gene is commonly expressed in the renal tumors: a new candidate marker for renal carcinogenesis.Oncogene · 2004Article
- A germ-line insertion in the Birt-Hogg-Dubé (BHD) gene gives rise to the Nihon rat model of inherited renal cancer.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Renal carcinogenesis: genotype, phenotype and dramatype.Cancer science · 2003Review
- A novel renal carcinoma predisposing gene of the Nihon rat maps on chromosome 10.Japanese journal of cancer research : Gann · 2001Article
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel rat model of hereditary renal cell carcinoma (RC) was found in a rat colony of the Sprague-Dawley strain in Japan, and named the rising "Nihon" rat. In this strain, RCs develop from early preneoplastic lesions, which begin to appear at 4 weeks of age, forming adenomas by the age of 16 weeks. The RCs are predominantly of clear cell type. Southern blot, northern blot and SSCP analyses revealed no change in the Tsc1, Tsc2, VHL, and c-Met genes. Thus, the Nihon rat should be a valuable experimental model for understanding renal carcinogenesis, especially clear cell type, which is common among human RCs.
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