ArticleJournal of the American College of Cardiology2000
Prognostic factors for atherosclerosis progression in saphenous vein grafts: the postcoronary artery bypass graft (Post-CABG) trial. Post-CABG Trial Investigators.
Article in Journal of the American College of Cardiology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00000463. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Post Coronary Artery Bypass Graft (CABG) Study
Effect of Alirocumab on Saphenous Vein Graft Atherosclerosis: The Alirocumab for Stopping Atherosclerosis Progression in Saphenous Vein Grafts (ASAP-SVG) Pilot Trial
Who cites it
27 citing papers in PubMed, 130 citations in OpenAlex.
- SUPERIOR SVG: no touch saphenous harvesting to improve patency following coronary bypass grafting (a multi-Centre randomized control trial, NCT01047449).Journal of cardiothoracic surgery · 2019Trial
- Saphenous vein graft failure after coronary artery bypass surgery: insights from PREVENT IV.Circulation · 2014Trial
- A multicentre, randomized, double-blind placebo-controlled trial evaluating rosiglitazone for the prevention of atherosclerosis progression after coronary artery bypass graft surgery in patients with type 2 diabetes. Design and rationale of the VeIn-Coronary aTherOsclerosis and Rosiglitazone after bypass surgerY (VICTORY) trial.The Canadian journal of cardiology · 2009Trial
- Depressive symptoms and the risk of atherosclerotic progression among patients with coronary artery bypass grafts.Circulation · 2008Trial
- The effect of blood lipids on the comorbidity of multiple large arachnoid granulations.Lipids in health and disease · 2024Article
- Time-varying effect of postoperative cholesterol profile on long-term outcomes of isolated coronary artery bypass graft surgery.Lipids in health and disease · 2023Article
- Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts.American heart journal · 2022Article
- Resilience of the Internal Mammary Artery to Atherogenesis: Shifting From Risk to Resistance to Address Unmet Needs.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- A Novel Risk Scoring Tool to Predict Saphenous Vein Graft Occlusion After Cardiac Artery Bypass Graft Surgery.Frontiers in cardiovascular medicine · 2021Article
- Article
- A comparative review of the outcomes of using arterial versus venous conduits in coronary artery bypass graft (CABG).Journal of family medicine and primary care · 2019Review
- Current State of the Art in Approaches to Saphenous Vein Graft Interventions.Interventional cardiology (London, England) · 2017Article
- Saphenous vein graft near-infrared spectroscopy imaging insights from the lipid core plaque association with clinical events near-infrared spectroscopy (ORACLE-NIRS) registry.Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions · 2017Article
- Plasma homocysteine levels are related to medium-term venous graft degeneration in coronary artery bypass graft patients.Anatolian journal of cardiology · 2016Article
- A patient with acute coronary syndrome and shock due to occlusion of both native coronaries and bypass grafts who was rescued by revascularization.Journal of cardiology cases · 2016Article
- Preoperative graft assessment in aortocoronary bypass surgery.Experimental and therapeutic medicine · 2016Article
- Postoperative Heparin-Mediated Extracorporeal Low-Density Lipoprotein Fibrinogen Precipitation Aphaeresis Prevents Early Graft Occlusion after Coronary Artery Bypass Grafting.Surgery journal (New York, N.Y.) · 2016Article
- Impact of statins and beta-blocker therapy on mortality after coronary artery bypass graft surgery.Cardiovascular diagnosis and therapy · 2015Article
- Predictive factors of late venous aortocoronary graft failure: ultrastructural studies.PloS one · 2013Article
- Preexisting high expression of matrix metalloproteinase-2 in tunica media of saphenous vein conduits is associated with unfavorable long-term outcomes after coronary artery bypass grafting.BioMed research international · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe study was done to assess patients in the Post-Coronary Artery Bypass Graft (Post-CABG) trial to determine prognostic factors for atherosclerosis progression.
backgroundSaphenous vein grafts (SVGs) are effective in relieving angina and, in certain patient subsets, in prolonging life. However, the progression of atherosclerosis in many of these grafts limits their usefulness.
methodsThe Post-CABG trial studied moderate versus aggressive lipid-lowering and low-dose warfarin versus placebo in patients with a history of coronary artery bypass surgery and found that more aggressive lipid lowering was effective in preventing progression of atherosclerosis in SVGs, but warfarin had no effect. Using variables measured at baseline, we sought the independent prognostic factors for atherosclerosis progression in SVGs, employing the statistical method of generalized estimating equations with a logit-link function.
resultsTwelve independent prognostic factors for atherosclerosis progression were found. In the order of their importance they were: maximum stenosis of the graft at baseline angiography, years post-SVG placement; the moderate low-density lipoprotein-cholesterol (LDL-C) lowering strategy; prior myocardial infarction; high triglyceride level; small minimum graft diameter; low high-density lipoprotein-cholesterol (HDL-C); high LDL-C; high mean arterial pressure; low ejection fraction; male gender; and current smoking.
conclusionsThis study identified Post-CABG patient and SVG characteristics associated with saphenous vein graft atherosclerosis progression. These data provide a basis for rational risk factor management to prevent progression of SVG atherosclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.