ArticleClinical and experimental immunology2000
Increased transforming growth factor-beta (TGF-beta)-secreting T cells and IgA anti-cardiolipin antibody levels during acute stage of childhood Henoch-Schönlein purpura.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 76 citations in OpenAlex.
- Alteration of gut microbiota in Henoch-Schönlein purpura children with gastrointestinal involvement.Irish journal of medical science · 2024Article
- Immunoglobulin A vasculitis: The clinical features and pathophysiology.The Kaohsiung journal of medical sciences · 2024Review
- Regulatory T and B cells in pediatric Henoch-Schönlein purpura: friends or foes?Arthritis research & therapy · 2024Article
- A Review of IgA Vasculitis (Henoch-Schönlein Purpura) Past, Present, and Future.Medical science monitor : international medical journal of experimental and clinical research · 2024Review
- Correlation between antiphospholipid antibodies and renal involvement in children with Henoch-Schönlein purpura: A cross-sectional study.Caspian journal of internal medicine · 2024Article
- Analysis of IL-1β, TGF-β, IL-5, ACE, PTPN22 gene polymorphisms, and gene expression levels in Turkish children with IgA vasculitis.Molecular biology reports · 2023Article
- A Review of the Mechanism of Vascular Endothelial Injury in Immunoglobulin A Vasculitis.Frontiers in physiology · 2022Review
- Lupus anticoagulant-hypoprothrombinemia syndrome and immunoglobulin-A vasculitis: a report of Japanese sibling cases and review of the literature.Rheumatology international · 2019Review
- Correlation between serum inflammatory factors TNF-α, IL-8, IL-10 and Henoch-Schonlein purpura with renal function impairment.Experimental and therapeutic medicine · 2018Article
- Correlation between invasion mode and the histologic risk assessment model in oral squamous cell carcinoma.Oral and maxillofacial surgery · 2016Article
- Article
- Antiphospholipid antibodies in children with Kawasaki disease: a preliminary study from north India.Rheumatology international · 2014Article
- Clinical significance of IgA anti-cardiolipin and IgA anti-β2glycoprotein I antibodies.Current rheumatology reports · 2013Review
- CTLA-4 exon 1 +49A/G polymorphism is associated with renal involvement in pediatric Henoch-Schönlein purpura.Pediatric nephrology (Berlin, Germany) · 2012Article
- Interleukin 8 gene 2767 A/G polymorphism is associated with increased risk of nephritis in children with Henoch-Schönlein purpura.Rheumatology international · 2012Article
- Henoch-Schonlein Purpura with thrombocythaemia: an abnormality in Smad4 expression?Rheumatology international · 2009Article
- CTLA-4 +49 A/G genotype and HLA-DRB1 polymorphisms in Turkish patients with Henoch-Schönlein purpura.Pediatric nephrology (Berlin, Germany) · 2008Article
- Massive gastrointestinal haemorrhage in isolated intestinal Henoch-Schonlein purpura with response to intravenous immunoglobulin infusion.European journal of pediatrics · 2007Article
- Circulating IgA from acute stage of childhood Henoch-Schönlein purpura can enhance endothelial interleukin (IL)-8 production through MEK/ERK signalling pathway.Clinical and experimental immunology · 2006Article
- Renal manifestations in Henoch-Schönlein purpura: a 10-year clinical study.Pediatric nephrology (Berlin, Germany) · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Henoch-Schönlein purpura (HSP) is a small vessel vasculitis characterized by increased serum IgA and IgA-dominant immune complex deposition in lesions. The involvement of IgA implies a probable role for TGF-beta, a major factor in IgA production, in the pathogenesis of HSP. Among IgA antibodies, serum IgA anti-cardiolipin antibodies (aCL) have been found in many diseases, including vasculitis. In addition to the clinical presentations and laboratory parameters, we further investigated the roles of IgA aCL and TGF-beta in childhood HSP. Twenty-six Chinese children with the diagnosis of HSP were enrolled. Blood samples from these patients were collected at both acute and convalescent stages. Intracellular staining of lymphocytes was performed to enumerate type 1 (interferon-gamma-secreting), type 2 (IL-4-secreting), and type 3 (TGF-beta-secreting) helper T cells. Serum levels of TGF-beta were detected by ELISA. Serum IgA aCL of 21 of 26 patients at the acute stage, 11 of them at the convalescent stage, were measured by ELISA. The data showed that IgA aCL serum levels were significantly elevated in patients compared with healthy controls (P < 0.001), and those patients at the convalescent stage (P < 0.001). In addition, TGF-beta-secreting T cells were significantly elevated during the acute stage, and decreased at the convalescent stage. Although more studies are needed, the high prevalence of IgA aCL and increased TGF-beta-secreting T cells in children with acute HSP revealed some points which should permit a better understanding of the pathogenesis of HSP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.