ArticleClinical and experimental immunology2000
Treatment with a monocolonal antibody to IL-8 attenuates the pleocytosis in experimental pneumococcal meningitis in rabbits when given intravenously, but not intracisternally.
Article in Clinical and experimental immunology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 35 citations in OpenAlex.
- Cytokine response in cerebrospinal fluid of meningitis patients and outcome associated with pneumococcal serotype.Scientific reports · 2021Article
- Role of neural barriers in the pathogenesis and outcome ofExperimental and therapeutic medicine · 2017Article
- Cerebrospinal-fluid cytokine and chemokine profile in patients with pneumococcal and meningococcal meningitis.BMC infectious diseases · 2013Article
- Role of oxidative stress in the pathophysiology of pneumococcal meningitis.Oxidative medicine and cellular longevity · 2013Review
- Cytokines and chemokines at the crossroads of neuroinflammation, neurodegeneration, and neuropathic pain.Mediators of inflammation · 2013Review
- Characterization of a pneumococcal meningitis mouse model.BMC infectious diseases · 2012Article
- Genetic variation of innate immune response genes in invasive pneumococcal and meningococcal disease applied to the pathogenesis of meningitis.Genes and immunity · 2011Review
- Pathogenesis and pathophysiology of pneumococcal meningitis.Clinical microbiology reviews · 2011Review
- Thrombopoietin contributes to neuronal damage in experimental bacterial meningitis.Infection and immunity · 2011Article
- Influence of the blood bacterial load on the meningeal inflammatory response in Streptococcus pneumoniae meningitis.BMC infectious diseases · 2006Article
- Chemotactic factors in cerebrospinal fluid during bacterial meningitis.Infection and immunity · 2006Review
- Down-regulation of IL-8 expression in human airway epithelial cells through helper-dependent adenoviral-mediated RNA interference.Cell research · 2005Article
- [Chemokine--possible new options for the treatment of multiple sclerosis].Der Nervenarzt · 2003Review
- Reprogramming the host response in bacterial meningitis: how best to improve outcome?Clinical microbiology reviews · 2003Review
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of interleukin (IL)-8 as mediator in the recruitment of leucocytes into the CSF was investigated during experimental pneumococcal meningitis. Rabbits were inoculated intracisternally with approximately 10(6) CFU Streptococcus pneumoniae, and treated (i) intravenously with 5 mg of a monoclonal antibody to IL-8 (n = 7) or 5 mg of an isotype control antibody (n = 6); (ii) intracisternally with anti-IL-8, 100 microg (n = 5), 10 microg (n = 4), 1 microg (n = 4), 0.1 microg (n = 2). Ten rabbits served as untreated control group. Intravenous treatment with anti-IL-8 attenuated the pleocytosis significantly compared to untreated rabbits (P < 0.04) or rabbits treated with an isotype control antibody (P < 0.02). In contrast, intracisternal treatment with anti-IL-8 failed to attenuate the pleocytosis (P > 0.05). These results show, that IL-8 plays an important role in the recruitment of leucocytes during experimental pneumococcal meningitis, and that the functional activity of IL-8 in this process appears to be on the bloodstream side of the microvascular endothelium of the brain.
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