ArticleJournal of virology2000
Identification of conserved residues contributing to the activities of adenovirus DNA polymerase.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Pathogenicity and Genomic Features of a DAdV-3 Strain Causing Severe Hepatitis in Muscovy Ducklings.Transboundary and emerging diseases · 2026Article
- Article
- Coexistence of adeno-associated virus 2 with adenovirus 18 or herpesvirus may be associated with severe lingual papillomatosis in an immunocompromised individual.Virologica Sinica · 2024Article
- Viral and cellular interactions during adenovirus DNA replication.FEBS letters · 2019Review
- An outbreak of acute respiratory disease caused by a virus associated RNA II gene mutation strain of human adenovirus 7 in China, 2015.PloS one · 2017Article
- Interregional Coevolution Analysis Revealing Functional and Structural Interrelatedness between Different Genomic Regions in Human Mastadenovirus D.Journal of virology · 2015Article
- Adenovirus DNA replication.Cold Spring Harbor perspectives in biology · 2013Review
- Selective modification of adenovirus replication can be achieved through rational mutagenesis of the adenovirus type 5 DNA polymerase.Journal of virology · 2012Article
- Twinkle and POLG defects enhance age-dependent accumulation of mutations in the control region of mtDNA.Nucleic acids research · 2004Article
- A 21-amino acid peptide from the cysteine cluster II of the family D DNA polymerase from Pyrococcus horikoshii stimulates its nuclease activity which is Mre11-like and prefers manganese ion as the cofactor.Nucleic acids research · 2004Article
- DNA binding properties of the adenovirus DNA replication priming protein pTP.Nucleic acids research · 2003Article
- Progressive external ophthalmoplegia characterized by multiple deletions of mitochondrial DNA: unraveling the pathogenesis of human mitochondrial DNA instability and the initiation of a genetic classification.Neuromolecular medicine · 2003Review
- Molecular architecture of adenovirus DNA polymerase and location of the protein primer.Journal of virology · 2002Article
- Terminal proteins essential for the replication of linear plasmids and chromosomes in Streptomyces.Genes & development · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Adenovirus codes for a DNA polymerase that is a member of the DNA polymerase alpha family and uses a protein primer for initiation of DNA synthesis. It contains motifs characteristic of a proofreading 3'-5'-exonuclease domain located in the N-terminal region and several polymerase motifs located in the C-terminal region. To determine the role of adenovirus DNA polymerase in DNA replication, 22 site-directed mutations were introduced into the conserved DNA polymerase motifs in the C-terminal region of adenovirus DNA polymerase and the mutant forms were expressed in insect cells using a baculovirus expression system. Each mutant enzyme was tested for DNA binding activity, the ability to interact with pTP, DNA polymerase catalytic activity, and the ability to participate in the initiation of adenovirus DNA replication. The mutant phenotypes identify functional domains within the adenovirus DNA polymerase and allow discrimination between the roles of conserved residues in the various activities carried out by the protein. Using the functional data in this study and the previously published structure of the bacteriophage RB69 DNA polymerase (J. Wang et al., Cell 89:1087-1099, 1997), it is possible to envisage how the conserved domains in the adenovirus DNA polymerase function.
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