ArticleJournal of virology2000
Analysis of individual human trigeminal ganglia for latent herpes simplex virus type 1 and varicella-zoster virus nucleic acids using real-time PCR.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 96 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
96 citing papers in PubMed, 184 citations in OpenAlex.
- Viral Spectrum of Herpetic Keratitis: A 15-Year Retrospective Analysis from Switzerland.Microorganisms · 2026Article
- Herpes stromal keratitis erodes the establishment of tissue-resident memory T cell pool in HSV-1 infected corneas.Mucosal immunology · 2025Article
- Reply to Wang et al., "Ample evidence for the presence of HSV-1 LAT in non-neuronal ganglionic cells of mice and humans".Journal of virology · 2024Article
- Emerging drugs for the treatment of herpetic keratitis.Expert opinion on emerging drugs · 2024Review
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- Laboratory Diagnosis of Mpox, Central African Republic, 2016-2022.Emerging infectious diseases · 2023Article
- Meningitis caused by the varicella vaccine virus in 17 immunized children and adolescents from the United States, Europe, and Japan.Annals of the Child Neurology Society · 2023Review
- Varicella Zoster Virus Neuronal Latency and Reactivation Modeled in Vitro.Current topics in microbiology and immunology · 2023Review
- Modulation of Apoptosis and Cell Death Pathways by Varicella-Zoster Virus.Current topics in microbiology and immunology · 2023Review
- High Efficacy of Saliva in Detecting SARS-CoV-2 by RT-PCR in Adults and Children.Microorganisms · 2021Article
- Typical gene expression profile of pseudorabies virus reactivation from latency in swine trigeminal ganglion.Journal of neurovirology · 2020Article
- Herpes Simplex Virus 1 Replication, Ocular Disease, and Reactivations from Latency Are Restricted Unilaterally after Inoculation of Virus into the Lip.Journal of virology · 2019Article
- Herpes simplex virus-1 (HSV-1) infection induces a potent but ineffective IFN-λ production in immune cells of AD and PD patients.Journal of translational medicine · 2019Article
- Persistence of a T Cell Infiltrate in Human Ganglia Years After Herpes Zoster and During Post-herpetic Neuralgia.Frontiers in microbiology · 2019Article
- Targeted Genome Sequencing Reveals Varicella-Zoster Virus Open Reading Frame 12 Deletion.Journal of virology · 2017Article
- Modeling HSV-1 Latency in Human Embryonic Stem Cell-Derived Neurons.Pathogens (Basel, Switzerland) · 2017Article
- Induction of varicella zoster virus DNA replication in dissociated human trigeminal ganglia.Journal of neurovirology · 2017Article
- Alphaherpesvirus DNA replication in dissociated human trigeminal ganglia.Journal of neurovirology · 2016Article
- SUNCT headaches after ipsilateral ophthalmic-distribution zoster.Journal of the neurological sciences · 2016Article
- Burning mouth syndrome associated with varicella zoster virus.BMJ case reports · 2016Article
36 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) establish latent infections in the peripheral nervous system following primary infection. During latency both virus genomes exhibit limited transcription, with the HSV-1 LATs and at least four VZV transcripts consistently detected in latently infected human ganglia. In this study we used real-time PCR quantitation to determine the viral DNA copy number in individual trigeminal ganglia (TG) from 17 subjects. The number of HSV-1 genomes was not significantly different between the left and right TG from the same individual and varied per subject from 42.9 to 677.9 copies per 100 ng of DNA. The number of VZV genomes was also not significantly different between left and right TG from the same individual and varied per subject from 37.0 to 3,560.5 copies per 100 ng of DNA. HSV-1 LAT transcripts were consistently detected in ganglia containing latent HSV-1 and varied in relative expression by >500-fold. Of the three VZV transcripts analyzed, only transcripts mapping to gene 63 were consistently detected in latently infected ganglia and varied in relative expression by >2,000-fold. Thus, it appears that, similar to LAT transcription in HSV-1 latently infected ganglia, VZV gene 63 transcription is a hallmark of VZV latency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.