ArticleGenes & development2000
Dual utilization of an acceptor/donor splice site governs the alternative splicing of the IRF-3 gene.
Article in Genes & development, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
- Interferon-Stimulated Gene-Mediated Defense Against Prion Infection: Noncanonical Function of Oas1a.Viruses · 2026Review
- The unusual gene architecture of polyubiquitin is created by dual-specific splice sites.Genome biology · 2024Article
- Alternative pre-mRNA splicing as a mechanism for terminating Toll-like Receptor signaling.Frontiers in immunology · 2022Review
- Review
- The Alternatively Spliced Isoforms of Key Molecules in the cGAS-STING Signaling Pathway.Frontiers in immunology · 2021Review
- Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-DependentViruses · 2020Review
- Alternative Pre-mRNA Splicing in Mammals and Teleost Fish: A Effective Strategy for the Regulation of Immune Responses Against Pathogen Infection.International journal of molecular sciences · 2017Review
- Article
- Protective role of interferon regulatory factor 3-mediated signaling against prion infection.Journal of virology · 2012Article
- Interferon regulatory factor 3-CL, an isoform of IRF3, antagonizes activity of IRF3.Cellular & molecular immunology · 2011Article
- Dual-specificity splice sites function alternatively as 5' and 3' splice sites.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Irf3 polymorphism alters induction of interferon beta in response to Listeria monocytogenes infection.PLoS genetics · 2007Article
- Manipulation of the toll-like receptor 7 signaling pathway by Epstein-Barr virus.Journal of virology · 2007Article
- Strengths and weaknesses of EST-based prediction of tissue-specific alternative splicing.BMC genomics · 2004Article
- Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation.Genome research · 2004Article
- Specific SR protein-dependent splicing substrates identified through genomic SELEX.Nucleic acids research · 2003Article
- Genome-wide detection of tissue-specific alternative splicing in the human transcriptome.Nucleic acids research · 2002Article
- Functional characterization of interferon regulatory factor 3a (IRF-3a), an alternative splice isoform of IRF-3.Molecular and cellular biology · 2001Article
- Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Interferon regulatory factors constitute a family of transcriptional activators and repressors involved in a large number of vital cellular processes. Interferon regulatory factor-3 (IRF-3) has been implicated in virus and double-stranded RNA mediated induction of IFNbeta and RANTES, in DNA damage signaling, and in virus-induced apoptosis. With its critical role in these pathways, the activity of IRF-3 is tightly regulated in myriad ways. Here we describe novel regulation of IRF-3 at the level of RNA splicing. We show that an unprecedented dual utilization of a splice acceptor/donor site within the IRF-3 mRNA governs the production of two alternative splice isoforms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.