ArticleProceedings of the National Academy of Sciences of the United States of America2000
The GABAB receptor interacts directly with the related transcription factors CREB2 and ATFx.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
58 citing papers in PubMed, 177 citations in OpenAlex.
- Activation of GABBR1 by New Ligand Valerate Transcriptionally Regulates ATF4-NRF2-CXCL13 Axis Mediating CD8International journal of biological sciences · 2026Article
- The First 30 Days Postnatal of the GABA Receptor: A Comprehensive Overview.Molecular neurobiology · 2025Review
- Review
- Keeping the Balance: GABABrain sciences · 2022Review
- Mechanisms and Regulation of Neuronal GABACurrent topics in behavioral neurosciences · 2022Review
- Oligodendroglial GABAergic Signaling: More Than Inhibition!Neuroscience bulletin · 2021Review
- ATF4 selectively regulates heat nociception and contributes to kinesin-mediated TRPM3 trafficking.Nature communications · 2021Article
- Diverse role of γ-aminobutyric acid in dynamic plant cell responses.Plant cell reports · 2019Review
- Influence of hippocampal GABAMetabolic brain disease · 2018Article
- Activating Transcription Factor 4 (ATF4) Regulates Neuronal Activity by Controlling GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Diversity of structure and function of GABAProceedings of the Japan Academy. Series B, Physical and biological sciences · 2018Review
- Neuronal Chloride Regulation via KCC2 Is Modulated through a GABAThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Adenosine A2B Receptor: From Cell Biology to Human Diseases.Frontiers in chemistry · 2016Review
- Functions of kinesin superfamily proteins in neuroreceptor trafficking.BioMed research international · 2015Review
- Compartmental distribution of GABAB receptor-mediated currents along the somatodendritic axis of hippocampal principal cells.Frontiers in synaptic neuroscience · 2015Article
- Hypothalamic eIF2α signaling regulates food intake.Cell reports · 2014Article
- Effect of GABAB receptor antagonist (CGP35348) on learning and memory in albino mice.TheScientificWorldJournal · 2014Article
- G proteins, p60TRP, and neurodegenerative diseases.Molecular neurobiology · 2013Review
- Allele-specific programming of Npy and epigenetic effects of physical activity in a genetic model of depression.Translational psychiatry · 2013Article
- Emerging neurotrophic role of GABAB receptors in neuronal circuit development.Frontiers in cellular neuroscience · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
gamma-Aminobutyric acid type B (GABA(B)) receptors mediate the metabotropic actions of the inhibitory neurotransmitter GABA. These seven-transmembrane receptors are known to signal primarily through activation of G proteins to modulate the action of ion channels or second messengers. The functional GABA(B) receptor is made up of a heterodimer consisting of two subunits, GABA(B)-R1 and GABA(B)-R2, which interact via coiled-coil domains in their C-terminal tails. By using a yeast two-hybrid approach, we have identified direct interactions between the C-terminal tails of GABA(B)-R1 and GABA(B)-R2 with two related transcription factors, CREB2 (ATF4) and ATFx. In primary neuronal cultures as well in recombinant Chinese hamster ovary cells expressing GABA(B) receptors, CREB2 is localized within the cytoplasm as well as the nucleus. Activation of the GABA(B) receptor by the specific agonist baclofen leads to a marked translocation and accumulation of CREB2 from the cytoplasm into the nucleus. We demonstrate that receptor stimulation results in activation of transcription from a CREB2 responsive reporter gene. Such a signaling mechanism is unique among Family C G protein-coupled receptors and, in the case of the GABA(B) receptor and CREB2, may play a role in long-term changes in the nervous system.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.