ArticleArchives of disease in childhood2000
Chasing the base deficit: hyperchloraemic acidosis following 0.9% saline fluid resuscitation.
Article in Archives of disease in childhood, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Perioperative balanced crystalloids versus normal saline during kidney transplantation: a systematic review and meta-analysis of randomized controlled trials.International urology and nephrology · 2024Pooled it
- 0.9% Saline versus Ringer's lactate as initial fluid in children with diabetic ketoacidosis: a double-blind randomized controlled trial.BMJ open diabetes research & care · 2025Trial
- Changes in acid-base and ion balance during exercise in normoxia and normobaric hypoxia.European journal of applied physiology · 2017Trial
- Lactate and base excess (BE) as markers of hypoperfusion and mortality in traumatic hemorrhagic shock in patients undergoing Damage Control: a historical cohort.Revista do Colegio Brasileiro de Cirurgioes · 2024Article
- Diabetic Ketoacidosis in Children and Adolescents; Diagnostic and Therapeutic Pitfalls.Diagnostics (Basel, Switzerland) · 2023Review
- Electrolyte derangements in critically ill children receiving balanced versus unbalanced crystalloid fluid resuscitation.BMC nephrology · 2022Observational
- The therapeutic importance of acid-base balance.Biochemical pharmacology · 2021Review
- Comparison of Commercially Available Balanced Salt Solution and Ringer's Lactate on Extent of Correction of Metabolic Acidosis in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Plasma-Lyte 148 and Plasma-Lyte 148 + 5% glucose compatibility with commonly used critical care drugs.Intensive care medicine experimental · 2020Article
- Diabetic ketoacidosis.Nature reviews. Disease primers · 2020Review
- Ab-normal saline in abnormal kidney function: risks and alternatives.Pediatric nephrology (Berlin, Germany) · 2019Review
- Comparison of Plasma-Lyte A and Sodium Chloride 0.9% for Fluid Resuscitation of Patients With Diabetic Ketoacidosis.Hospital pharmacy · 2018Article
- Hyperchloremia is independently associated with mortality in critically ill children who ultimately require continuous renal replacement therapy.Pediatric nephrology (Berlin, Germany) · 2018Article
- Resuscitation fluid composition affects hepatic inflammation in a murine model of early sepsis.Intensive care medicine experimental · 2017Article
- The great fluid debate: saline or so-called "balanced" salt solutions?Italian journal of pediatrics · 2015Review
- Evaluation of the efficacy of simplified Fencl-Stewart equation in analyzing the changes in acid base status following resuscitation with two different fluids.International journal of critical illness and injury science · 2013Article
- Chloride Balance in Preterm Infants during the First Week of Life.International journal of pediatrics · 2012Article
- Fluid management on hospital medical wards.Clinical medicine (London, England) · 2010Review
- Diabetic ketoacidosis.BMJ (Clinical research ed.) · 2007Article
- Fluid resuscitation of hypovolemic shock: acute medicine's great triumph for children.Intensive care medicine · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Base deficit is a parameter often used to guide further treatment in acidotic children and is taken as a measure of how "sick" they are. Five children with septic shock are presented who had persisting base deficit after large volume resuscitation with 0.9% saline. Stewart's strong ion theory of acid-base balance is able to quantify the causes of metabolic acidosis and is used to show that our patients had a hyperchloraemic metabolic acidosis. We show how the chloride content of the saline loads given to our patients caused this hyperchloraemia. It is concluded that 0.9% saline and other chloride rich fluids may not be ideal resuscitation fluids; if used, clinicians must be aware of their potential to cause a persistent base deficit.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.