ArticleThe Journal of clinical investigation2000
Roles of Fas and Fas ligand during mammary gland remodeling.
Article in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Mesenchymal stem cell-derived apoptotic vesicles ameliorate impaired ovarian folliculogenesis in polycystic ovary syndrome and ovarian aging by targeting WNT signaling.Theranostics · 2024Article
- Reconstruction of dynamic mammary mini gland in vitro for normal physiology and oncogenesis.Nature methods · 2023Article
- Genome-Wide Association Study for Udder Conformation Traits in Chinese Holstein Cattle.Animals : an open access journal from MDPI · 2022Article
- Deciphering the roles of lncRNAs in breast development and disease.Oncotarget · 2018Review
- The role of toll-like receptors in colorectal cancer progression: evidence for epithelial to leucocytic transition.Frontiers in immunology · 2014Review
- The serum miR-21 level serves as a predictor for the chemosensitivity of advanced pancreatic cancer, and miR-21 expression confers chemoresistance by targeting FasL.Molecular oncology · 2013Article
- The Signaling Mechanism of TGF-β1 Induced Bovine Mammary Epithelial Cell Apoptosis.Asian-Australasian journal of animal sciences · 2012Article
- Article
- TIMP3 regulates mammary epithelial apoptosis with immune cell recruitment through differential TNF dependence.PloS one · 2011Article
- Analysis of inhibitor of apoptosis protein family expression during mammary gland development.BMC developmental biology · 2010Article
- CXCR1 blockade selectively targets human breast cancer stem cells in vitro and in xenografts.The Journal of clinical investigation · 2010Article
- The contribution of dynamic stromal remodeling during mammary development to breast carcinogenesis.Breast cancer research : BCR · 2010Review
- Mammary involution and breast cancer risk: transgenic models and clinical studies.Journal of mammary gland biology and neoplasia · 2009Review
- Homology with vesicle fusion mediator syntaxin-1a predicts determinants of epimorphin/syntaxin-2 function in mammary epithelial morphogenesis.The Journal of biological chemistry · 2009Article
- Lactation failure in Src knockout mice is due to impaired secretory activation.BMC developmental biology · 2008Article
- Relationship between expression of hepatocyte grow factor and apoptosis of trophoblasts in hypertensive disorder complicating pregnancy.Frontiers of medicine in China · 2007Article
- Mammary gland involution as a multi-step process.Journal of mammary gland biology and neoplasia · 2007Review
- The beginning of the end: death signaling in early involution.Journal of mammary gland biology and neoplasia · 2007Review
- Hsp70 may protect cardiomyocytes from stress-induced injury by inhibiting Fas-mediated apoptosis.Cell stress & chaperones · 2007Article
- Estrogens up-regulate the Fas/FasL apoptotic pathway in lactotropes.Endocrinology · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Mammary involution is associated with degeneration of the alveolar structure and programmed cell death of mammary epithelial cells. In this study, we evaluated the expression of Fas and Fas ligand (FasL) in the mammary gland tissue and their possible role in the induction of apoptosis of mammary cells. FasL-positive cells were observed in normal mammary epithelium from pregnant and lactating mice, but not in nonpregnant/virgin mouse mammary tissue. Fas expression was observed in epithelial and stromal cells in nonpregnant mice but was absent during pregnancy. At day 1 after weaning, high levels of both Fas and FasL proteins and caspase 3 were observed and coincided with the appearance of apoptotic cells in ducts and glands. During the same period, no apoptotic cells were found in the Fas-deficient (MRL/lpr) and FasL-deficient (C3H/gld) mice. Increase in Fas and FasL protein was demonstrated in human (MCF10A) and mouse (HC-11) mammary epithelial cells after incubation in hormone-deprived media, before apoptosis was detected. These results suggest that the Fas-FasL interaction plays an important role in the normal remodeling of mammary tissue. Furthermore, this autocrine induction of apoptosis may prevent accumulation of cells with mutations and subsequent neoplastic development. Failure of the Fas/FasL signal could contribute to tumor development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.