Evidence map›Paper›PMID 11086020›Full record

ReviewThe Journal of clinical investigation2000

The mechanisms of estrogen regulation of bone resorption.

B L Riggs

Abstract readCommentReview
In one paragraph

Review in The Journal of clinical investigation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 181 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
181citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

181 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. State of the art systematic review of bone disease in anorexia nervosa.The International journal of eating disorders · 2016
    Pooled it
  4. Pooled it
  5. Strategies to reverse bone loss in women with functional hypothalamic amenorrhea: a systematic review of the literature.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2008
    Pooled it
  6. The efficacy of calcium supplementation alone in elderly Thai women over a 2-year period: a randomized controlled trial.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2013
    Trial
  7. Contribution of serum inflammatory markers to changes in bone mineral content and density in postmenopausal women: a 1-year investigation.Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry
    Trial
  8. Prognostic value of serum estradiol and sclerostin for predicting fracture healing in postmenopausal women with osteoporotic vertebral compression fractures.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Review
  13. Metabolic Signatures of FourMetabolites · 2025
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. The Role of Estrogen across Multiple Disease Mechanisms.Current issues in molecular biology · 2024
    Review

121 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

B L RiggsEndocrine Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA. riggs.lawrence@mayo.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBone ResorptionCarrier ProteinsEstrogensGlycoproteinsHumansInterleukin-1Interleukin-6LigandsMacrophage Colony-Stimulating FactorMembrane GlycoproteinsOsteoclastsOsteoprotegerinRANK LigandReceptor Activator of Nuclear Factor-kappa BReceptors, Cytoplasmic and NuclearCarrier ProteinsEstrogensGlycoproteinsInterleukin-1Interleukin-6LigandsMacrophage Colony-Stimulating FactorMembrane GlycoproteinsOsteoprotegerinRANK LigandReceptor Activator of Nuclear Factor-kappa BReceptors, Cytoplasmic and NuclearReceptors, Tumor Necrosis FactorTNFRSF11A protein, humanTNFRSF11B protein, humanTNFSF11 protein, humanTumor Necrosis Factor-alpha

Identifiers

PMID11086020
PMCPMC381441

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.