ArticleThe Biochemical journal2000
All natural DR3-type vitamin D response elements show a similar functionality in vitro.
Article in The Biochemical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- Vitamin D for the treatment of multiple sclerosis: a meta-analysis.Journal of neurology · 2018Pooled it
- 1α,25(OH)(2)-Vitamin D3 increases dysferlin expression in vitro and in a human clinical trial.Molecular therapy : the journal of the American Society of Gene Therapy · 2012Trial
- The Role of Vitamin D in Neuropathic Pain: Biological Mechanisms and Clinical Relevance.International journal of molecular sciences · 2026Review
- Targeting nuclear receptors in muscular dystrophies and regenerative myogenesis.Frontiers in cell and developmental biology · 2026Review
- Genomic regions occupied by both RARα and VDR are involved in the convergence and cooperation of retinoid and vitamin D signaling pathways.Nucleic acids research · 2025Article
- Calcitriol induces estrogen receptor α expression through direct transcriptional regulation and epigenetic modifications in estrogen receptor-negative breast cancer cells.American journal of cancer research · 2021Article
- Overexpression of the vitamin D receptor (VDR) induces skeletal muscle hypertrophy.Molecular metabolism · 2020Article
- No Association between Polymorphisms of Vitamin D and Oxytocin Receptor Genes and Autistic Spectrum Disorder in a Sample of Turkish Children.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2018Article
- Novel VDR antagonists based on the GW0742 scaffold.Bioorganic & medicinal chemistry letters · 2018Article
- Identification of genetic variants affecting vitamin D receptor binding and associations with autoimmune disease.Human molecular genetics · 2017Article
- Pre-treatment VD levels and VDR receptors as potential predictors of occurrence and overall survival in paediatric patients with solid tumours-a single institution pilot study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Tight junction CLDN2 gene is a direct target of the vitamin D receptor.Scientific reports · 2015Article
- The paracrine feedback loop between vitamin D₃ (1,25(OH)₂D₃) and PTHrP in prehypertrophic chondrocytes.Journal of cellular physiology · 2014Article
- Structural considerations of vitamin D signaling.Frontiers in physiology · 2014Review
- Patterns of genome-wide VDR locations.PloS one · 2014Article
- Peroxisome proliferation-activated receptor δ agonist GW0742 interacts weakly with multiple nuclear receptors, including the vitamin D receptor.Biochemistry · 2013Article
- 1,25-Dihydroxyvitamin D3 suppresses telomerase expression and human cancer growth through microRNA-498.The Journal of biological chemistry · 2012Article
- Discovery of the first irreversible small molecule inhibitors of the interaction between the vitamin D receptor and coactivators.Journal of medicinal chemistry · 2012Article
- Environmental risk factors for multiple sclerosis: a review with a focus on molecular mechanisms.International journal of molecular sciences · 2012Review
- Vitamin D binding protein and monocyte response to 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D: analysis by mathematical modeling.PloS one · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The vitamin D(3) receptor (VDR), which is the nuclear receptor for 1alpha,25-dihydroxyvitamin D(3) [1alpha,25(OH)(2)D(3)], acts primarily as a heterodimer with the retinoid X receptor (RXR) and binds preferentially to directly repeated arrangements of two hexameric binding sites with three spacing nucleotides [DR3-type vitamin D response elements (VDREs)]. In this study, all presently known natural DR3-type VDREs have been compared and classified on the basis of their complex-formation with VDR-RXR heterodimers and their ability to stabilize VDR-RXR heterodimer conformations. Based on the affinity of each VDRE for VDR-RXR heterodimers, the DR3-type VDREs were divided into three classes. The ligand sensitivity of this complex-formation and conformational stabilization was determined to be in the range of 0.1 nM. No significant differences in the 1alpha,25(OH)(2)D(3)-modulated interactions of the DR3-type VDRE-complexed VDR-RXR heterodimer with the co-activator SRC-1 (steroid receptor co-activator-1) or the co-repressor NCoR (nuclear receptor co-repressor) were found. Taken together, the affinity for VDR-RXR heterodimers appears to be the major discriminating parameter between natural DR3-type VDREs. This will not only facilitate further investigation of the principles of DR3-type-VDRE-mediated gene regulation, but also strongly suggests that DR3-type VDREs alone cannot explain the pleiotropic genomic action of 1alpha,25(OH)(2)D(3).
Indexed as
Identifiers
11085922PMC1221460W2104829608What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.