ArticleAmerican journal of human genetics2001
Extent and distribution of linkage disequilibrium in three genomic regions.
Article in American journal of human genetics, 2001. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 3 of them syntheses that pooled it.
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Who cites it
102 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Imputing Phenotypes for Genome-wide Association Studies.American journal of human genetics · 2016Pooled it
- A systematic review of cancer GWAS and candidate gene meta-analyses reveals limited overlap but similar effect sizes.European journal of human genetics : EJHG · 2014Pooled it
- Association between HLA-B*46 allele and Graves disease in Asian populations: a meta-analysis.International journal of medical sciences · 2013Pooled it
- Exploring imputation performance of phenotype-associated SNPs for forensic prediction models.Scientific reports · 2026Article
- Minor Allele Frequency Filtering Can Strongly Bias Uniqueness Estimates Within and Across Species.Ecology and evolution · 2026Article
- Genome-wide association studies reveal genetic control of nutritional quality, milling traits, and agronomic characteristics in oat (Avena sativa L.).The plant genome · 2025Article
- Extremely sparse models of linkage disequilibrium in ancestrally diverse association studies.Nature genetics · 2023Article
- Genomic-environmental associations in wild cranberry (Vaccinium macrocarpon Ait.).G3 (Bethesda, Md.) · 2022Article
- Further insight into the global variability of the OCA2-HERC2 locus for human pigmentation from multiallelic markers.Scientific reports · 2021Article
- Linkage Disequilibrium and Effective Population Size of Buffalo Populations of Iran, Turkey, Pakistan, and Egypt Using a Medium Density SNP Array.Frontiers in genetics · 2021Article
- Genetic architecture of complex traits and disease risk predictors.Scientific reports · 2020Article
- Stationary distribution of the linkage disequilibrium coefficient rTheoretical population biology · 2019Article
- Combined effects of multiple linked loci on pairwise sibling tests.International journal of legal medicine · 2017Article
- Colocalization of GWAS and eQTL Signals Detects Target Genes.American journal of human genetics · 2016Article
- Evaluation of power of the Illumina HumanOmni5M-4v1 BeadChip to detect risk variants for human complex diseases.European journal of human genetics : EJHG · 2016Article
- Environmental Association Analyses Identify Candidates for Abiotic Stress Tolerance in Glycine soja, the Wild Progenitor of Cultivated Soybeans.G3 (Bethesda, Md.) · 2016Article
- Using local multiplicity to improve effect estimation from a hypothesis-generating pharmacogenetics study.The pharmacogenomics journal · 2016Article
- Runs of Homozygosity: Association with Coronary Artery Disease and Gene Expression in Monocytes and Macrophages.American journal of human genetics · 2015Article
- Genetic Structure of and Evidence for Admixture between Western and Korean Native Pig Breeds Revealed by Single Nucleotide Polymorphisms.Asian-Australasian journal of animal sciences · 2014Article
- Genetic mapping of high caries experience on human chromosome 13.BMC medical genetics · 2013Article
42 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The positional cloning of genes underlying common complex diseases relies on the identification of linkage disequilibrium (LD) between genetic markers and disease. We have examined 127 polymorphisms in three genomic regions in a sample of 575 chromosomes from unrelated individuals of British ancestry. To establish phase, 800 individuals were genotyped in 160 families. The fine structure of LD was found to be highly irregular. Forty-five percent of the variation in disequilibrium measures could be explained by physical distance. Additional factors, such as allele frequency, type of polymorphism, and genomic location, explained <5% of the variation. Nevertheless, disequilibrium was occasionally detectable at 500 kb and was present for over one-half of marker pairs separated by <50 kb. Although these findings are encouraging for the prospects of a genomewide LD map, they suggest caution in interpreting localization due to allelic association.
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