ArticleInfection and immunity2000
Characterization of bactericidal immune responses following vaccination with acellular pertussis vaccines in adults.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- Acellular pertussis vaccines and complement killing of Bordetella pertussis.Infection and immunity · 2004Trial
- Development of High-Throughput Serum Bactericidal Assays forVaccines · 2026Article
- Development of carbohydrate based next-generation anti-pertussis vaccines.Bioorganic & medicinal chemistry · 2022Review
- Vaccine-Induced Cellular Immunity againstVaccines · 2021Review
- Acellular Pertussis Vaccines Induce Anti-pertactin Bactericidal Antibodies Which Drives the Emergence of Pertactin-Negative Strains.Frontiers in microbiology · 2020Article
- Article
- Single Amino Acid Polymorphisms of Pertussis Toxin Subunit S2 (PtxB) Affect Protein Function.PloS one · 2015Article
- Toward a new vaccine for pertussis.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Immunization of teenagers with a fifth dose of reduced DTaP-IPV induces high levels of pertussis antibodies with a significant increase in opsonophagocytic activity.Clinical and vaccine immunology : CVI · 2011Article
- Antibodies recognizing protective pertussis toxin epitopes are preferentially elicited by natural infection versus acellular immunization.Clinical and vaccine immunology : CVI · 2011Article
- Characterization of a key neutralizing epitope on pertussis toxin recognized by monoclonal antibody 1B7.Biochemistry · 2009Article
- Opsonophagocytic activity and other serological indications of Bordetella pertussis infection in military recruits in Norway.Clinical and vaccine immunology : CVI · 2007Article
- Differential in vitro expression of the brkA gene in Bordetella pertussis and Bordetella parapertussis clinical isolates.Journal of clinical microbiology · 2006Article
- Influence of CR3 (CD11b/CD18) expression on phagocytosis of Bordetella pertussis by human neutrophils.Infection and immunity · 2005Article
- Growth phase influences complement resistance of Bordetella pertussis.Infection and immunity · 2002Article
- Pertussis toxin and lipopolysaccharide influence phagocytosis of Bordetella pertussis by human monocytes.Infection and immunity · 2001Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Sera from six adults, collected before and after acellular pertussis vaccination, and from a placebo control were examined for the ability to elicit two bactericidal immune defenses, (i) antibody-dependent complement-mediated bacterial lysis and (ii) opsonization and phagocytosis by human neutrophils. The samples were chosen based on low preimmunization titers and strong postimmunization responses to various combinations of vaccine antigens. All but two prevaccination samples demonstrated activity indicative of complement-mediated lysis. Preimmunization activity could have been due to prior infection or childhood immunization. Immunization did not result in improved bactericidal activity for any of the individuals, and in two cases immunization caused a statistically significant decrease in complement-mediated lysis. Similarly, opsonization with the postimmunization sera failed to enhance attachment or phagocytosis of bacteria by neutrophils, and one postimmunization sample with a strong response to filamentous hemagglutinin caused an inhibition of phagocytosis that was statistically significant compared to that observed for the no-serum control. In summary, booster immunization of adults with acellular pertussis vaccines was not found to increase bactericidal activity over preimmunization levels. Identifying ways to promote bactericidal immune responses might improve the efficacy of acellular pertussis vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.