ArticleInfection and immunity2000
Human CD8(+) T cells specific for Mycobacterium tuberculosis secreted antigens in tuberculosis patients and healthy BCG-vaccinated controls in The Gambia.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 74 citations in OpenAlex.
- Immunodominant Tuberculosis Antigens Recognized by Human CD4Cold Spring Harbor perspectives in medicine · 2026Article
- An RNA-Based Vaccine Platform for Use againstVaccines · 2023Article
- Immunogenicity and protection against Mycobacterium avium with a heterologous RNA prime and protein boost vaccine regimen.Tuberculosis (Edinburgh, Scotland) · 2023Article
- Accelerating research and development of new vaccines against tuberculosis: a global roadmap.The Lancet. Infectious diseases · 2022Review
- It Takes a Village: The Multifaceted Immune Response toFrontiers in immunology · 2022Review
- Diagnostic Potential of the Serological Response to Synthetic Peptides fromInternational journal of peptide research and therapeutics · 2022Article
- Diagnostic Potential of IgG and IgA Responses toMicroorganisms · 2020Article
- Diminished Frequencies of Cytotoxic Marker Expressing T- and NK Cells at the Site ofFrontiers in immunology · 2020Article
- PD-1 Expression onFrontiers in immunology · 2018Article
- Decreased expression of perforin in CD8Journal of thoracic disease · 2017Article
- Excessive Cytolytic Responses Predict Tuberculosis Relapse After Apparently Successful Treatment.The Journal of infectious diseases · 2016Article
- Antigens for CD4 and CD8 T cells in tuberculosis.Cold Spring Harbor perspectives in medicine · 2014Review
- Early diagnosis of tuberculous meningitis by an indirect ELISA protocol based on the detection of the antigen ESAT-6 in cerebrospinal fluid.Irish journal of medical science · 2014Article
- Article
- Mycobacterium tuberculosis multidrug resistant strain M induces an altered activation of cytotoxic CD8+ T cells.PloS one · 2014Article
- Cytotoxic response persists in subjects treated for tuberculosis decades ago.BMC infectious diseases · 2013Article
- Pleural mesothelial cells promote expansion of IL-17-producing CD8+ T cells in tuberculous pleural effusion.Journal of clinical immunology · 2013Article
- Functional capacity of Mycobacterium tuberculosis-specific T cell responses in humans is associated with mycobacterial load.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Immunologic analysis of HIV-uninfected Taiwanese children with BCG-induced disease.Journal of clinical immunology · 2009Article
- Lack of immune responses to Mycobacterium tuberculosis DosR regulon proteins following Mycobacterium bovis BCG vaccination.Infection and immunity · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 4 countries.
Funding
Abstract
Intracellular flow cytometry analysis of perforin production by CD8(+) T cells showed levels were greatly reduced in tuberculosis (TB) patients compared to healthy controls. Reduced cytotoxic-T-lymphocyte activity was also obtained with CD8(+) T cells from TB patients compared to healthy controls in The Gambia. A change in antigen recognition was noted between the two groups of donors: in addition to recognition of Ag85A and Ag85B, as seen in healthy donors, a prominent ESAT-6 response was found in TB patients.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.