ArticleInfection and immunity2000
mig-14 is a horizontally acquired, host-induced gene required for salmonella enterica lethal infection in the murine model of typhoid fever.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- Cross-species genomic analysis ofOne health (Amsterdam, Netherlands) · 2026Article
- How the PhoP/PhoQ System Controls Virulence and MgMicrobiology and molecular biology reviews : MMBR · 2021Review
- On the in vivo significance of bacterial resistance to antimicrobial peptides.Biochimica et biophysica acta · 2015Review
- S. Typhimurium strategies to resist killing by cationic antimicrobial peptides.Biochimica et biophysica acta · 2015Review
- Analysis of the Pantoea ananatis pan-genome reveals factors underlying its ability to colonize and interact with plant, insect and vertebrate hosts.BMC genomics · 2014Article
- Salmonella Typhimurium TTSS-2 deficient mig-14 mutant shows attenuation in immunocompromised mice and offers protection against wild-type Salmonella Typhimurium infection.BMC microbiology · 2013Article
- Comprehensive assignment of roles for Salmonella typhimurium genes in intestinal colonization of food-producing animals.PLoS genetics · 2013Article
- An in vivo platform for rapid high-throughput antitubercular drug discovery.Cell reports · 2012Article
- The Xanthomonas campestris pv. vesicatoria citH gene is expressed early in the infection process of tomato and is positively regulated by the TctDE two-component regulatory system.Molecular plant pathology · 2011Article
- Functional identification of the Proteus mirabilis core lipopolysaccharide biosynthesis genes.Journal of bacteriology · 2010Article
- Genome-wide transposon mutagenesis identifies a role for host neuroendocrine stress hormones in regulating the expression of virulence genes in Salmonella.Journal of bacteriology · 2010Article
- Unraveling the secret lives of bacteria: use of in vivo expression technology and differential fluorescence induction promoter traps as tools for exploring niche-specific gene expression.Microbiology and molecular biology reviews : MMBR · 2005Review
- Antigen selection based on expression levels during infection facilitates vaccine development for an intracellular pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Overrepresentation of a gene family encoding extracytoplasmic solute receptors in Bordetella.Journal of bacteriology · 2003Article
- Characterization of a novel intracellularly activated gene from Salmonella enterica serovar typhi.Infection and immunity · 2002Article
- mig-14 is a Salmonella gene that plays a role in bacterial resistance to antimicrobial peptides.Journal of bacteriology · 2002Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
We have characterized a host-induced virulence gene, mig-14, that is required for fatal infection in the mouse model of enteric fever. mig-14 is present in all Salmonella enterica subspecies I serovars and maps to a region of the chromosome that appears to have been acquired by horizontal transmission. A mig-14 mutant replicated in host tissues early after infection but was later cleared from the spleens and livers of infected animals. Bacterial clearance by the host occurred concomitantly with an increase in gamma interferon levels and recruitment of macrophages, but few neutrophils, to the infection foci. We hypothesize that the mig-14 gene product may repress immune system functions by interfering with normal cytokine expression in response to bacterial infections.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.