ArticleInfection and immunity2000
Characterization of allelic variation in the Babesia bovis merozoite surface antigen 1 (MSA-1) locus and identification of a cross-reactive inhibition-sensitive MSA-1 epitope.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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32 citing papers in PubMed, 88 citations in OpenAlex.
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- Characterization of the variable merozoite surface antigen (VMSA) gene family of Babesia orientalis.Parasitology research · 2020Article
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- Unravelling the cellular and molecular pathogenesis of bovine babesiosis: is the sky the limit?International journal for parasitology · 2019Review
- Babesia bovis RON2 contains conserved B-cell epitopes that induce an invasion-blocking humoral immune response in immunized cattle.Parasites & vectors · 2018Article
- Geno- and phenotypic characteristics of a transfected Babesia bovis 6-Cys-E knockout clonal line.Parasites & vectors · 2017Article
- Evaluation of a Major Surface Antigen ofFrontiers in microbiology · 2017Article
- A recombinant multi-antigen vaccine formulation containing Babesia bovis merozoite surface antigens MSA-2aParasites & vectors · 2016Article
- Identification and characterization of the RouenBd1987 Babesia divergens Rhopty-Associated Protein 1.PloS one · 2014Article
- Targeted surface expression of an exogenous antigen in stably transfected Babesia bovis.PloS one · 2014Article
- The genetic diversity of merozoite surface antigen 1 (MSA-1) among Babesia bovis detected from cattle populations in Thailand, Brazil and Ghana.The Journal of veterinary medical science · 2013Article
- Validation and field evaluation of a competitive enzyme-linked immunosorbent assay for diagnosis of Babesia bovis infections in Argentina.Clinical and vaccine immunology : CVI · 2012Article
- CD4 T cell antigens from Staphylococcus aureus Newman strain identified following immunization with heat-killed bacteria.Clinical and vaccine immunology : CVI · 2012Article
- Coinfection with antigenically and genetically distinct virulent strains of Babesia bovis is maintained through all phases of the parasite life cycle.Infection and immunity · 2007Article
- A shared antigen among Babesia species: ribosomal phosphoprotein P0 as a universal babesial vaccine candidate.Parasitology research · 2007Article
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Babesia bovis merozoite surface antigen 1 (MSA-1), a member of the variable merozoite surface antigen (VMSA) family, is an immunodominant glycoprotein which elicits antibodies that inhibit erythrocyte invasion. While antigenic polymorphism is a general feature of vmsa genes, the molecular basis and extent of msa-1 sequence polymorphism have not been well characterized. In this study we defined the msa-1 locus in the biologically cloned Mexico Mo7 strain of B. bovis and identified the sequence differences between MSA-1 antigenically dissimilar strains. We then determined whether sequences conserved between distinct msa-1 alleles would induce cross-reactive CD4(+) T lymphocytes or inhibitory antibodies. The msa-1 locus in Mo7 contains a single msa-1 gene flanked by transcribed genes with no sequence homology to members of the VMSA gene family. Argentina B. bovis strains R1A and S2P have msa-1 genes with amino acid sequences that are 98.8% identical to each other, and antibodies against S2P MSA-1 cross-react with native R1A MSA-1. In contrast, identity between the Argentina and Mexico Mo7 msa-1 alleles is only 52%, with no continuous stretch of identity longer than 16 amino acids. Despite limited sequence conservation, antibodies against R1A MSA-1 were able to inhibit invasion of erythrocytes by Mo7 merozoites. The results indicate that inhibition-sensitive epitopes are conserved despite significant sequence divergence between Mexico and Argentina strain alleles and support a conserved functional role for polymorphic MSA-1 in erythrocyte invasion.
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