ArticleInfection and immunity2000
Bacterial pathogens induce abscess formation by CD4(+) T-cell activation via the CD28-B7-2 costimulatory pathway.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- From the Friend to the Foe-International journal of molecular sciences · 2024Review
- Natural and synthetic carbohydrate-based vaccine adjuvants and their mechanisms of action.Nature reviews. Chemistry · 2021Review
- Pathogenic potential ofBMJ case reports · 2020Article
- CD80/CD86 signaling contributes to the proinflammatory response of Staphylococcus aureus in the airway.Cytokine · 2018Article
- Review
- Both anti-TNF and CTLA4 Ig treatments attenuate the disease severity of staphylococcal dermatitis in mice.PloS one · 2017Article
- The interplay between microbiota and inflammation: lessons from peritonitis and sepsis.Clinical & translational immunology · 2016Review
- Interaction of the Capsular Polysaccharide A from Bacteroides fragilis with DC-SIGN on Human Dendritic Cells is Necessary for Its Processing and Presentation to T Cells.Frontiers in immunology · 2013Article
- The dynamics of T cells during persistent Staphylococcus aureus infection: from antigen-reactivity to in vivo anergy.EMBO molecular medicine · 2011Article
- TCA cycle inactivation in Staphylococcus aureus alters nitric oxide production in RAW 264.7 cells.Molecular and cellular biochemistry · 2011Article
- Role of T lymphocytes in liver abscess formation by Bacteroides fragilis in mice.Infection and immunity · 2011Article
- Article
- Streptococcus pneumoniae serotype 1 capsular polysaccharide induces CD8CD28 regulatory T lymphocytes by TCR crosslinking.PLoS pathogens · 2009Article
- Oligoclonal CD4+ T cells promote host memory immune responses to Zwitterionic polysaccharide of Streptococcus pneumoniae.Infection and immunity · 2009Article
- Differential role for CD80 and CD86 in the regulation of the innate immune response in murine polymicrobial sepsis.PloS one · 2009Article
- CD40 and CD80/86 act synergistically to regulate inflammation and mortality in polymicrobial sepsis.American journal of respiratory and critical care medicine · 2008Article
- Dysregulated immune profiles for skin and dendritic cells are associated with increased host susceptibility to Haemophilus ducreyi infection in human volunteers.Infection and immunity · 2007Article
- Transport of Streptococcus pneumoniae capsular polysaccharide in MHC Class II tubules.PLoS pathogens · 2007Article
- A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2.The Journal of experimental medicine · 2006Article
- CD4+ T cells and CXC chemokines modulate the pathogenesis of Staphylococcus aureus wound infections.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
Abstract
Abscesses are a classic host response to infection by many pathogenic bacteria. The immunopathogenesis of this tissue response to infection has not been fully elucidated. Previous studies have suggested that T cells are involved in the pathologic process, but the role of these cells remains unclear. To delineate the mechanism by which T cells mediate abscess formation associated with intra-abdominal sepsis, the role of T-cell activation and the contribution of antigen-presenting cells via CD28-B7 costimulation were investigated. T cells activated in vitro by zwitterionic bacterial polysaccharides (Zps) known to induce abscess formation required CD28-B7 costimulation and, when adoptively transferred to the peritoneal cavity of naïve rats, promoted abscess formation. Blockade of T-cell activation via the CD28-B7 pathway in animals with CTLA4Ig prevented abscess formation following challenge with different bacterial pathogens, including Staphylococcus aureus, Bacteroides fragilis, and a combination of Enterococcus faecium and Bacteroides distasonis. In contrast, these animals had an increased abscess rate following in vivo T-cell activation via CD28 signaling. Abscess formation in vivo and T-cell activation in vitro required costimulation by B7-2 but not B7-1. These results demonstrate that abscess formation by pathogenic bacteria is under the control of a common effector mechanism that requires T-cell activation via the CD28-B7-2 pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.