ArticleInfection and immunity2000
Regulation of the Porphyromonas gingivalis fimA (Fimbrillin) gene.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 36 citations in OpenAlex.
- Influences of race/ethnicity in periodontal treatment response and bacterial distribution, a cohort pilot study.Frontiers in oral health · 2023Article
- A Tale of Two Fimbriae: How Invasion of Dendritic Cells byPathogens (Basel, Switzerland) · 2022Review
- Role of FAD-I in Fusobacterial Interspecies Interaction and Biofilm Formation.Microorganisms · 2020Article
- Comparative gene expression analysis of planktonic Porphyromonas gingivalis ATCC 33277 in the presence of a growing biofilm versus planktonic cells.BMC microbiology · 2019Article
- Salmonella grows vigorously on seafood and expresses its virulence and stress genes at different temperature exposure.BMC microbiology · 2015Article
- Article
- Genetic exchange of fimbrial alleles exemplifies the adaptive virulence strategy of Porphyromonas gingivalis.PloS one · 2014Article
- Microbial interactions in building of communities.Molecular oral microbiology · 2013Review
- Porphyromonas gingivalis fimbriae.Journal of oral microbiology · 2013Article
- Beyond the red complex and into more complexity: the polymicrobial synergy and dysbiosis (PSD) model of periodontal disease etiology.Molecular oral microbiology · 2012Review
- Abrogation of neuraminidase reduces biofilm formation, capsule biosynthesis, and virulence of Porphyromonas gingivalis.Infection and immunity · 2012Article
- Fusobacterium nucleatum-associated beta-defensin inducer (FAD-I): identification, isolation, and functional evaluation.The Journal of biological chemistry · 2010Article
- Subgingival biofilm formation.Periodontology 2000 · 2010Review
- Defensins attenuate cytokine responses yet enhance antibody responses to Porphyromonas gingivalis adhesins in mice.Future microbiology · 2010Article
- Negative correlation of distributions of Streptococcus cristatus and Porphyromonas gingivalis in subgingival plaque.Journal of clinical microbiology · 2009Article
- Human alpha- and beta-defensins bind to immobilized adhesins from Porphyromonas gingivalis.Infection and immunity · 2008Article
- Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.Frontiers in bioscience : a journal and virtual library · 2008Review
- Mutational analysis of the ompA promoter from Flavobacterium johnsoniae.Journal of bacteriology · 2007Article
- Porphyromonas gingivalis short fimbriae are regulated by a FimS/FimR two-component system.FEMS microbiology letters · 2007Article
- Porphyromonas gingivalis genes involved in fimA regulation.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
In common with many bacterial virulence genes, the fimbrillin (fimA) gene of Porphyromonas gingivalis is modulated in response to environmental fluctuation. The trans-acting components that comprise the regulatory system for transcriptional activity of the fimA gene in P. gingivalis were investigated. Three major proteins were found to bind to the upstream region of the fimA promoter. One of these proteins was fimbrillin itself, and the other two were a major arginine protease (Rgp) and lysine protease (Kgp). Production of these proteins was necessary for maximal fimA transcription. An exogenous fimA promoter-lacZ reporter was inactive when introduced into a strain of P. gingivalis carrying a mutation in the indigenous fimA gene. Furthermore, fimA mRNA levels were significantly decreased in rgp and kgp mutant strains. These data indicate that P. gingivalis has evolved multiple levels of control of fimbrial gene expression to enhance its survival in hostile environments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.