ArticleAntimicrobial agents and chemotherapy2000
Two new mechanisms of macrolide resistance in clinical strains of Streptococcus pneumoniae from Eastern Europe and North America.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 2 of them syntheses that pooled it.
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Who cites it
79 citing papers in PubMed, 2 syntheses or guidelines pooled it, 255 citations in OpenAlex.
- Antimicrobial treatment guidelines for acute bacterial rhinosinusitis.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2004Guideline
- Update of practice guidelines for the management of community-acquired pneumonia in immunocompetent adults.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2003Guideline
- Article
- An alternative approach to combat multidrug-resistant bacteria: new insights into traditional Chinese medicine monomers combined with antibiotics.Advanced biotechnology · 2025Review
- Unravelling Antimicrobial Resistance inVeterinary sciences · 2024Review
- Article
- Azithromycin resistance mutations inMicrobial genomics · 2020Article
- Multistate population and whole genome sequence-based strain surveillance of invasive pneumococci recovered in the USA during 2017.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2020Article
- Staphylococcus aureus with an erm-mediated constitutive macrolide-lincosamide-streptogramin B resistance phenotype has reduced susceptibility to the new ketolide, solithromycin.BMC infectious diseases · 2019Article
- Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus.Nucleic acids research · 2017Article
- The macrolide antibiotic renaissance.British journal of pharmacology · 2017Review
- Ribosomal Mutations Conferring Macrolide Resistance in Legionella pneumophila.Antimicrobial agents and chemotherapy · 2017Article
- Resistance to Macrolide Antibiotics in Public Health Pathogens.Cold Spring Harbor perspectives in medicine · 2016Review
- Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective.Clinical microbiology reviews · 2016Review
- Mobile elements and chromosomal changes associated with MLS resistance phenotypes of invasive pneumococci recovered in the United States.Microbial drug resistance (Larchmont, N.Y.) · 2015Article
- Antimicrobial susceptibility and analysis of macrolide resistance genes in Streptococcus pneumoniae isolated in Hamadan.Iranian journal of basic medical sciences · 2014Article
- Microbiological characterization of Streptococcus pneumoniae and non-typeable Haemophilus influenzae isolates as primary causes of acute otitis media in Bulgarian children before the introduction of conjugate vaccines.Annals of clinical microbiology and antimicrobials · 2013Article
- Article
- Comparison of transformation frequencies among selected Streptococcus pneumoniae serotypes.International journal of antimicrobial agents · 2010Article
- Phenotypic and genetic characteristics of macrolide and lincosamide resistant Ureaplasma urealyticum isolated in Guangzhou, China.Current microbiology · 2010Article
19 more citing papers are in PubMed but not listed here.
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Resistance to macrolides in pneumococci is generally mediated by methylation of 23S rRNA via erm(B) methylase which can confer a macrolide (M)-, lincosamide (L)-, and streptogramin B (S(B))-resistant (MLS(B)) phenotype or by drug efflux via mef(A) which confers resistance to 14- and 15-membered macrolides only. We studied 20 strains with unusual ML or MS(B) phenotypes which did not harbor erm(B) or mef(A). The strains had been isolated from patients in Eastern Europe and North America from 1992 to 1998. These isolates were found to contain mutations in genes for either 23S rRNA or ribosomal proteins. Three strains from the United States with an ML phenotype, each representing a different clone, were characterized as having an A2059G (Escherichia coli numbering) change in three of the four 23S rRNA alleles. Susceptibility to macrolides and lincosamides decreased as the number of alleles in isogenic strains containing A2059G increased. Sixteen MS(B) strains from Eastern Europe were found to contain a 3-amino-acid substitution ((69)GTG(71) to TPS) in a highly conserved region of the ribosomal protein L4 ((63)KPWRQKGTGRAR(74)). These strains formed several distinct clonal types. The single MS(B) strain from Canada contained a 6-amino-acid L4 insertion ((69)GTGREKGTGRAR), which impacted growth rate and also conferred a 500-fold increase in MIC on the ketolide telithromycin. These macrolide resistance mechanisms from clinical isolates are similar to those recently described for laboratory-derived mutants.
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