ArticleAntimicrobial agents and chemotherapy2000
Photoactive porphyrin derivative with broad-spectrum activity against oral pathogens In vitro.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 114 citations in OpenAlex.
- Antimicrobial effect of photodynamic therapy using sinoporphyrin sodium and 390-400 nm light-emitting diode on Porphyromonas gingivalis in vitro.Lasers in medical science · 2021Article
- Application of Porphyrins in Antibacterial Photodynamic Therapy.Molecules (Basel, Switzerland) · 2019Review
- Novel Bioactive and Therapeutic Dental Polymeric Materials to Inhibit Periodontal Pathogens and Biofilms.International journal of molecular sciences · 2019Review
- Bacterial keratitis: Photodynamic inactivation reduced experimental inflammation.Experimental and therapeutic medicine · 2017Article
- Influence of H2TOEtPyP4 porphyrin on the stability and conductivity of bilayer lipid membranes.European biophysics journal : EBJ · 2015Article
- Antimicrobial action from a novel porphyrin derivative in photodynamic antimicrobial chemotherapy in vitro.Lasers in medical science · 2015Article
- Bactericidal effect of visible light in the presence of erythrosine on Porphyromonas gingivalis and Fusobacterium nucleatum compared with diode laser, an in vitro study.Laser therapy · 2014Article
- Impact of photodynamic inactivation (PDI) using the photosensitizer chlorin e6 on viability, apoptosis, and proliferation of human corneal endothelial cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2013Article
- Bacteriophage amplification assay for detection of Listeria spp. using virucidal laser treatment.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2012Article
- The effect of antimicrobial photodynamic therapy with radachlorin and toluidine blue on streptococcus mutans: an in vitro study.Journal of dentistry (Tehran, Iran) · 2011Article
- Drug discovery of antimicrobial photosensitizers using animal models.Current pharmaceutical design · 2011Review
- Effect of overall charge and charge distribution on cellular uptake, distribution and phototoxicity of cationic porphyrins in HEp2 cells.Journal of photochemistry and photobiology. B, Biology · 2010Article
- Decontamination efficacy of erbium:yttrium-aluminium-garnet and diode laser light on oral Candida albicans isolates of a 5-day in vitro biofilm model.Lasers in medical science · 2009Article
- Vaccines and photodynamic therapies for oral microbial-related diseases.Current drug metabolism · 2009Review
- Toluidine blue-mediated photoinactivation of periodontal pathogens from supragingival plaques.Lasers in medical science · 2008Article
- Protease-stable polycationic photosensitizer conjugates between polyethyleneimine and chlorin(e6) for broad-spectrum antimicrobial photoinactivation.Antimicrobial agents and chemotherapy · 2006Article
- Monitoring photodynamic therapy of localized infections by bioluminescence imaging of genetically engineered bacteria.Journal of photochemistry and photobiology. B, Biology · 2005Article
- Virulence of Pseudomonas aeruginosa cells surviving photodynamic treatment with toluidine blue.Current microbiology · 2005Article
- Photodynamic effects of novel XF porphyrin derivatives on prokaryotic and eukaryotic cells.Antimicrobial agents and chemotherapy · 2005Article
- Use of merocyanine 540 for photodynamic inactivation of Staphylococcus aureus planktonic and biofilm cells.Applied and environmental microbiology · 2004Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Photodynamic therapy (PDT) has historically been used as a means to treat cancerous tumors but has recently been used to kill bacterial cells through the use of targeted photosensitizers. PDT is a potential adjunct to scaling and root planing in the treatment of periodontal disease. However, the effectiveness of porphyrin derivatives against microorganisms has been limited because some gram-negative bacteria are refractory to photodynamic treatment with these agents. We have designed a porphyrin derivative conjugated to a pentalysine moeity that endows the molecule with activity against gram-positive and gram-negative bacteria. Whereas the porphyrin, chlorin e6, showed in vitro activity against a limited spectrum of bacteria, chlorin e6 conjugated to pentalysine showed in vitro activity against all oral microorganisms tested, including Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, Bacteroides forsythus, Campylobacter rectus, Eikenella corrodens, Fusobacterium nucleatum subsp. polymorphum, Actinomyces viscosus, and the streptococci. Potent antimicrobial activity (>/=5-log-unit reduction in the numbers of CFU per milliliter) was retained in the presence of up to 25% whole sheep blood. The use of potent, selective agents such as this chlorin e6-pentalysine conjugate to more effectively reduce the pathogenic bacteria in the periodontal pocket may be a significant tool for the treatment of periodontal disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.