ArticleBritish journal of pharmacology2000
Mechanisms of the cutaneous vasodilator response to local external pressure application in rats: involvement of CGRP, neurokinins, prostaglandins and NO.
Article in British journal of pharmacology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- Alpha-Lipoic Acid Supplementation Restores Early Age-Related Sensory and Endothelial Dysfunction in the Skin.Biomedicines · 2022Article
- Plasma Levels of CGRP During a 2-h Infusion of VIP in Healthy Volunteers and Patients With Migraine: An Exploratory Study.Frontiers in neurology · 2022Article
- Inflammation-linked adaptations in dermal microvascular reactivity accompany the development of obesity and type 2 diabetes.International journal of obesity (2005) · 2019Article
- Alteration of Pressure-Induced Vasodilation in Aging and Diabetes, a Neuro-Vascular Damage.Frontiers in physiology · 2019Article
- Pressure-induced vasodilation mimicking vasculopathy in a pediatric patient.JAAD case reports · 2016Article
- [Perianal and rectal ulcers due to abuse of paracetamol-codeine suppositories].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015Article
- Candesartan restores pressure-induced vasodilation and prevents skin pressure ulcer formation in diabetic mice.Cardiovascular diabetology · 2015Article
- Age-related changes in spontaneous oscillations assessed by wavelet transform of cerebral oxygenation and arterial blood pressure signals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Asic3 is a neuronal mechanosensor for pressure-induced vasodilation that protects against pressure ulcers.Nature medicine · 2012Article
- Influence of compression pressure from the hand access device on hand microcirculation during hand-assisted laparoscopic surgery.Surgical endoscopy · 2009Article
- Endothelium-derived hyperpolarizing factor as an in vivo back-up mechanism in the cutaneous microcirculation in old mice.The Journal of physiology · 2007Article
- Laser Doppler perfusion monitoring and imaging: novel approaches.Medical & biological engineering & computing · 2007Review
- Altered acetylcholine, bradykinin and cutaneous pressure-induced vasodilation in mice lacking the TREK1 potassium channel: the endothelial link.EMBO reports · 2007Article
- Neuroendocrine pathway involvement in the loss of the cutaneous pressure-induced vasodilatation during acute pain in rats.The Journal of physiology · 2007Article
- Evidence for the involvement of VPAC1 and VPAC2 receptors in pressure-induced vasodilatation in rodents.The Journal of physiology · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Local pressure-induced vasodilation (PIV) is a neural vasodilator response to non-nociceptive externally applied pressure in the skin, previously described in humans. We first determined whether PIV exists in rats and depends on capsaicin-sensitive fibres as it does in humans. We then examined the mediators involved in the efferent pathway of PIV. 2. Cutaneous blood flow was measured by laser Doppler flowmetry during 11.1 Pa s(-1) increases in local applied pressure in anaesthetized rats. The involvement of capsaicin-sensitive fibres in PIV was tested in rats treated neonatally with capsaicin. To antagonize CGRP, neurokinin-1, -2, or -3 receptors, different groups of rats were treated with CGRP(8 - 37), SR140333, SR48968 or SR142801, respectively. Prostaglandins involvement was tested with indomethacin treatment. To inhibit nitric oxide synthase (NOS) activity or specific neuronal NOS, rats were treated with N(G)-nitro-L-arginine or 7-nitroindazole, respectively. 3. PIV was found in rats, as in humans. PIV was abolished by neonatal treatment with capsaicin and by administration of CGRP(8 - 37) but remained unchanged with SR140333, SR48968 and SR142801 treatments. Prostaglandin inhibition resulted in a significant decrease in PIV. Inhibition of NOS abolished PIV, whereas inhibition of neuronal NOS caused a diminution of PIV. 4. These data suggest that PIV depends on capsaicin-sensitive fibres in rats, as in humans. It appears that CGRP plays a major role in the PIV, whereas neurokinins have no role. Furthermore, PIV involves a contribution from prostaglandins and depends on endothelial NO, whereas neuronal NO has a smaller role.
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